2-甲基-6-丙基哌啶 | 68170-79-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 中文名称: 2-甲基-6-丙基哌啶
• 英文名称: dihydropinidine
• 英文别名: 2-Methyl-6-propylpiperidine
• CAS: 68170-79-6
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: BHBZNQCZKUGKCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-戊炔-2-醇 在 palladium 10% on activated carbon 、 氢气 、 三苯基膦 、 copper(l) chloride 、 potassium hydroxide 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 乙酸乙酯 为溶剂， -10.0~105.0 ℃ 、101.33 kPa 条件下， 反应 24.0h， 生成 2-甲基-6-丙基哌啶
  参考文献：
  名称：

  A³-Coupling Reaction as a Strategy Towards the Synthesis of Alkaloids

  摘要：

  A number of aldehydes, alkynols and benzylamines were submitted to A(3)-coupling reaction, under CuCl catalysis, giving strategically functionalized hydroxy-propargylamines. The procedure allows the use of alkyl as well as aryl aldehydes. Representative substrates were converted into five- and six-membered cyclic alkaloids by sequential one-pot N-debenzylation/triple bond reduction promoted by Pd, followed by a Mitsunobu-type cyclization.

  DOI：

  10.5935/0103-5053.20140223

文献信息

• Solenopsin a, b and analogs and as novel angiogenesis inhibitors
  申请人：Bowen Phillip J.

  公开号：US20050038071A1

  公开（公告）日：2005-02-17

  The present invention relates to solenopsin A and its analogs for use as angiogenesis inhibitors. The present compounds unexpectedly exhibit good activity as angiogenesis inhibitors, which find use as antitumor/anticancer agents as well as to treat a number of conditions or disease states in which angiogenesis is a factor.

  本发明涉及用于作为血管生成抑制剂的溶蚁毒素A及其类似物。本化合物意外地表现出良好的作为血管生成抑制剂的活性，可用作抗肿瘤/抗癌剂以及治疗许多与血管生成有关的疾病状态。
• .alpha.-Amino carbanions via formamidines. Alkylation of pyrrolidines, piperidines, and related heterocycles
  作者：A. I. Meyers、Philip D. Edwards、William F. Rieker、Thomas R. Bailey

  DOI：10.1021/ja00323a035

  日期：1984.5
• Organoaluminum-promoted Beckmann rearrangement of oxime sulfonates
  作者：Keiji Maruoka、Tohru Miyazaki、Mamoru Ando、Yasushi Matsumura、Soichi Sakane、Kazunobu Hattori、Hisashi Yamamoto

  DOI：10.1021/ja00347a052

  日期：1983.5
• Successive Beckmann rearrangement-alkylation sequence by organoaluminum reagents. Simple route to dl-pumiliotoxin C
  作者：Kazunobu Hattori、Yasushi Matsumura、Tohru Miyazaki、Keiji Maruoka、Hisashi Yamamoto

  DOI：10.1021/ja00414a071

  日期：1981.12
• An in situ generated samarium complex as a practical catalyst for the efficient intramolecular hydroamination of non-activated alkenes
  作者：Coralie Quinet、Ali Ates、István E. Markó

  DOI：10.1016/j.tetlet.2008.06.053

  日期：2008.8

  Mixing Sml(2) and NaN(TMS)(2) generates in situ an efficient catalyst that promotes the intramolecular hychoamination of non-activated olefins. A wide range of aminoolefins can be cyclised smoothly using this simple protocol. Mechanistic studies led to the identification of the putative active catalyst. (c) 2008 Elsevier Ltd. All rights reserved.