(4'-chloro-4-methylbiphenyl-3-yl)acetyl chloride | 244159-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4'-chloro-4-methylbiphenyl-3-yl)acetyl chloride
• 英文别名: 2-[5-(4-chlorophenyl)-2-methylphenyl]acetyl chloride
• CAS: 244159-41-9
• 化学式: C₁₅H₁₂Cl₂O
• 分子量: 279.166
• InChiKey: IQPIXFHUVOSPFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4'-chloro-4-methylbiphenyl-3-yl)acetyl chloride 在 4-二甲氨基吡啶 、 sodium methylate 、 三乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 8-[5-(4-Chlorophenyl)-2-methylphenyl]-3-methoxy-1,2,4,5-tetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione
  参考文献：
  名称：

  结合有5-甲氧基-[1,2,5]三氮杂环庚烷环的除草芳基二酮

  摘要：

  探索了一种新型的含有5-甲氧基-[1,2,5]三氮杂环庚烷单元的2-芳基环-1,3-二酮，以有效，小麦安全地控制草杂草。他们的制备建立在易于合成7元杂环[1,2,5]三氮庚烷结构单元的基础上。苯基部分的取代和模式跳跃显示出结构活性关系与先前公开的乙酰辅酶A羧化酶抑制剂oxoxaden家族之间的观察结果一致。鉴于基本的物理化学，酶抑制和结合位点性质，N-甲氧基官能团有效地充当七元肼环中醚基的生物等排体。

  DOI：

  10.1016/j.bmcl.2017.12.042
• 作为产物：
  描述：

  (4'-chloro-4-methylbiphenyl-3-yl)acetic acid 在 氯化亚砜 作用下， 反应 4.0h， 以100%的产率得到(4'-chloro-4-methylbiphenyl-3-yl)acetyl chloride
  参考文献：
  名称：

  (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT

  摘要：

  本发明涉及(5s,8s)-3-(4'-氯-3'-氟-4-甲基联苯-3-基)-4-羟基-8-甲氧基-1-氮杂螺[4.5]癸-3-烯-2-酮在治疗用途上的应用，以及制药组合物和它们在治疗中的使用，特别是在预防和治疗肿瘤疾病方面的应用。

  公开号：

  US20140031407A1

文献信息

• CYCLIC KETO-ENOLS FOR THERAPY
  申请人：Liu Ningshu

  公开号：US20130040935A1

  公开（公告）日：2013-02-14

  The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.

  该发明涉及用于治疗目的的5'-联苯取代环状酮醇，药物组合物以及它们在治疗中的使用，特别是用于预防和治疗肿瘤疾病。
• Herbicidally and Insecticidally Active Thiazolopyridinones
  申请人：BAYER INTELLECTUAL PROPERTY GMBH

  公开号：US20150045217A1

  公开（公告）日：2015-02-12

  Thiazolopyridinones of the general formula (I) are described as herbicides. In this formula (I), R 1 , R 2 , R 3 and R 4 represent radicals such as hydrogen, organic radicals such as alkyl and other radicals such as halogen, nitro and cyano.

  通式(I)的噻唑吡啶酮被描述为除草剂。在这个式子(I)中，R1、R2、R3和R4代表氢、烷基等有机基团，以及卤素、硝基和氰基等其他基团。
• (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT
  申请人：Liu Ningshu

  公开号：US20140031407A1

  公开（公告）日：2014-01-30

  The invention relates to (5s,8s)-3-(4′-chloro-3′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.

  本发明涉及(5s,8s)-3-(4'-氯-3'-氟-4-甲基联苯-3-基)-4-羟基-8-甲氧基-1-氮杂螺[4.5]癸-3-烯-2-酮在治疗用途上的应用，以及制药组合物和它们在治疗中的使用，特别是在预防和治疗肿瘤疾病方面的应用。
• SUBSTITUTED 3-(BIPHENYL-3-YL)-8,8-DIFLUORO-4-HYDROXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONES FOR THERAPY AND HALOGEN-SUBSTITUTED SPIROCYCLIC KETOENOLS
  申请人：Bretschneider Thomas

  公开号：US20140045696A1

  公开（公告）日：2014-02-13

  The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, A, B, D and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or fungicides. The invention also relates to selective herbicidal compositions comprising, firstly, the halogen-substituted spirocyclic ketoenols and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, halogen-substituted spirocyclic ketoenols, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as pesticides and/or fungicides and/or for preventing unwanted plant growth. The invention also relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumor disorders.

  本发明涉及公式（I）的新化合物，其中W，X，Y，Z，A，B，D和G具有上述给定的含义，以及其制备的多种过程和中间体，以及它们作为杀虫剂和/或除草剂和/或杀菌剂的用途。本发明还涉及选择性除草剂组合物，其包括第一，卤代螺环酮烯醇，第二，作物植物相容性改良化合物。本发明还涉及通过向相应的组合物添加铵盐或膦盐和可选的渗透剂，从而提高特别是卤代螺环酮烯醇的作物保护组合物的作用的方法，以及生产它们的过程和它们在作物保护中作为杀虫剂和/或杀菌剂和/或防止不良植物生长的应用。本发明还涉及公式（Ia）的取代3-（联苯基-3-基）-8,8-二氟-4-羟基-1-氮杂螺[4.5]癸-3-烯-2-酮，用于治疗目的，以及制药组合物和它们在治疗中的用途，特别是用于肿瘤疾病的预防和治疗。
• Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy and halogen-substituted spirocyclic ketoenols
  申请人：Bretschneider Thomas

  公开号：US08946124B2

  公开（公告）日：2015-02-03

  The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, A, B, D and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or fungicides. The invention also relates to selective herbicidal compositions comprising, firstly, the halogen-substituted spirocyclic ketoenols and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, halogen-substituted spirocyclic ketoenols, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as pesticides and/or fungicides and/or for preventing unwanted plant growth. The invention also relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumor disorders.

  该发明涉及式(I)的新化合物，其中W、X、Y、Z、A、B、D和G具有上述给定的含义，以及它们的制备的多种过程和中间体，以及它们作为杀虫剂和/或除草剂和/或杀菌剂的用途。该发明还涉及选择性除草剂组合物，包括第一，卤代螺环酮烯醇，第二，改善作物植株相容性的化合物。本发明还涉及通过向相应的组合物添加铵盐或磷酸盐和可选的渗透剂，增强以卤代螺环酮烯醇为特征的作物保护组合物的作用的方法，以及生产它们的过程和它们在作物保护中作为杀虫剂和/或杀菌剂和/或预防不良植物生长的用途。该发明还涉及式(Ia)的取代3-(联苯基-3-基)-8,8-二氟-4-羟基-1-氮杂螺[4.5]癸-3-烯-2-酮，用于治疗目的，以及药物组合物和它们在治疗中的用途，特别是用于预防和治疗肿瘤疾病。