4-(Cyanoethyl)-4-<3-(benzyloxy)propyl>-1,7-bis(benzyloxy)heptane | 135646-72-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(Cyanoethyl)-4-<3-(benzyloxy)propyl>-1,7-bis(benzyloxy)heptane
• 英文别名: 7-Phenylmethoxy-4,4-bis(3-phenylmethoxypropyl)heptanenitrile
• CAS: 135646-72-9
• 化学式: C₃₄H₄₃NO₃
• 分子量: 513.72
• InChiKey: GCYDQQBVRYRFPS-UHFFFAOYSA-N

物化性质

• 沸点：
  646.5±55.0 °C(Predicted)
• 密度：
  1.054±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  38
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  51.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(Cyanoethyl)-4-<3-(benzyloxy)propyl>-1,7-bis(benzyloxy)heptane 在 sodium tetrahydroborate 、 硫酸 、 氢溴酸 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 27.0h， 生成 Tetrakis(3-bromopropyl)methane
  参考文献：
  名称：

  Micelles series. 31. Building blocks for cascade polymers. 11. Synthesis of functionalized cascade cores: tetrakis(.omega.-bromoalkyl)methanes

  摘要：

  A series of tetrakis(bromoalkyl)methanes was synthesized and characterized. The tetrakis(3-bromopropyl)methane was chosen as ideal core to cascade polymers, since it undergoes facile substitution with bulky nucleophiles, denoting the need for at least three carbon atoms between the quaternary center and the leaving group to circumvent major steric problems caused by the core carbon. The readily available 4-nitro-4-(3-hydroxypropyl)-1,7-heptanediol was used to afford a novel entry to tetrakis(3-bromopropyl)methane as well as other building blocks to cascade polymers.

  DOI：

  10.1021/jo00056a023
• 作为产物：
  描述：

  4-(3-羟基丙基)-4-硝基-1,7-庚二醇 在 氢氧化钾 、 2,2'-azobis(4-methylpropionitrile) 、 三正丁基氢锡 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 反应 4.0h， 生成 4-(Cyanoethyl)-4-<3-(benzyloxy)propyl>-1,7-bis(benzyloxy)heptane
  参考文献：
  名称：

  Micelles series. 31. Building blocks for cascade polymers. 11. Synthesis of functionalized cascade cores: tetrakis(.omega.-bromoalkyl)methanes

  摘要：

  A series of tetrakis(bromoalkyl)methanes was synthesized and characterized. The tetrakis(3-bromopropyl)methane was chosen as ideal core to cascade polymers, since it undergoes facile substitution with bulky nucleophiles, denoting the need for at least three carbon atoms between the quaternary center and the leaving group to circumvent major steric problems caused by the core carbon. The readily available 4-nitro-4-(3-hydroxypropyl)-1,7-heptanediol was used to afford a novel entry to tetrakis(3-bromopropyl)methane as well as other building blocks to cascade polymers.

  DOI：

  10.1021/jo00056a023

文献信息

• Solid Substrate Comprising Array of Dendrons and Methods for Using the Same
  申请人：Park Joon Won

  公开号：US20100093553A1

  公开（公告）日：2010-04-15

  The present invention provides solid supports comprising a surface bound array of dendrons and methods for using the same.

  本发明提供了固体支撑体，其包括表面结合的树枝状分子阵列，以及使用它们的方法。
• BIOMOLECULE INTERACTION USING ATOMIC FORCE MICROSCOPE
  申请人：Park Joon-Won

  公开号：US20080113353A1

  公开（公告）日：2008-05-15

  The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the dendron are bound to the surface, and a terminus of the linear region of the dendron is functionalized.
• US8673621B2
  申请人：——

  公开号：US8673621B2

  公开（公告）日：2014-03-18
• US9175335B2
  申请人：——

  公开号：US9175335B2

  公开（公告）日：2015-11-03
• US9201067B2
  申请人：——

  公开号：US9201067B2

  公开（公告）日：2015-12-01