1-bromomethyl-1-methoxycyclobutane | 30800-71-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-bromomethyl-1-methoxycyclobutane
• 英文别名: 1-Brommethyl-1-methoxycyclobutan；1-(Bromomethyl)-1-methoxycyclobutane
• CAS: 30800-71-6
• 化学式: C₆H₁₁BrO
• 分子量: 179.057
• InChiKey: FCQKZXITDZGVOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  甲醇 、 亚甲基环丁烷 在 N-溴代丁二酰亚胺(NBS) 作用下， 反应 2.0h， 以91%的产率得到1-bromomethyl-1-methoxycyclobutane
  参考文献：
  名称：

  摘要：

  The anti-Markownikoff products of bromination and bromomethoxylation of 3-methylenecyclo-butane-1-carbonitrile and methyl 3-methylenecyclobutane-1-carboxylate were subjected to dehydrobromination by the action of potassium tert-butoxide in THE The reaction takes two elimination pathways: 1,3-de-hydrobromination to give bicyclobutane derivatives and 1,2-dehydrobromination leading to substituted methylenecyclobutane. Structural factors in the substrate were revealed, which are responsible for the ratio of the two concurrent elimination processes.

  DOI：

  10.1023/a:1023486427682

文献信息

• Bromohydrins of methylenecyclobutane
  作者：Karen L. Erickson、Kyongtae Kim

  DOI：10.1021/jo00818a052

  日期：1971.9
• ——
  作者：V. V. Razin

  DOI：10.1023/a:1023486427682

  日期：——

  The anti-Markownikoff products of bromination and bromomethoxylation of 3-methylenecyclo-butane-1-carbonitrile and methyl 3-methylenecyclobutane-1-carboxylate were subjected to dehydrobromination by the action of potassium tert-butoxide in THE The reaction takes two elimination pathways: 1,3-de-hydrobromination to give bicyclobutane derivatives and 1,2-dehydrobromination leading to substituted methylenecyclobutane. Structural factors in the substrate were revealed, which are responsible for the ratio of the two concurrent elimination processes.