((1S)-trans-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | 3416-05-5

• 物质功能分类: 生物化工 - 核苷类药物 - 核苷酸及其类似物
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: ((1S)-trans-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
• 英文别名: 2-(5-Methyl-uracil-1-yl)-5-hydroxymethyltetrahydrofuran；1-[(5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 3416-05-5；69350-87-4；81276-36-0；121786-60-5；133008-04-5；144490-02-8
• 化学式: C₁₀H₁₄N₂O₄
• 分子量: 226.232
• InChiKey: XKKCQTLDIPIRQD-JAMMHHFISA-N

物化性质

• 熔点：
  155-156 °C(lit.)
• 比旋光度：
  20 º (C=0.6 IN H2O)
• 密度：
  1.332±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：25 mg/mL，DMF:PBS (pH 7.2) (1:5)：0.16 mg/mL，DMSO：20 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  29349990
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

用途：抗病毒和抗癌的研究工具。

文献信息

• Aryl Phosphate Derivatives of d4T having Activity Against Resistant HIV Strains
  申请人：Uckun M. Fatih

  公开号：US20070015733A1

  公开（公告）日：2007-01-18

  Methods of inhibiting virus replication of in a cell infected with a resistant strain of HIV that includes administering to the infected cell a virus replication inhibiting amount of an aryl phosphate derivative of d4T.

  抑制耐药HIV感染细胞中病毒复制的方法包括向感染的细胞中投入一定量的d4T的芳基磷酸酯衍生物，以抑制病毒的复制。
• TAU-TARGETING OLIGONUCLEOTIDE GAPMERS
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US20220195437A1

  公开（公告）日：2022-06-23

  Antisense oligonucleotides are provided. These antisense oligonucleotides are useful in the preparation of gapmers for inhibition of Tau mRNA transcription. Inhibition of Tau mRNA transcription may result in decrease of amounts of Tau protein in a subject, allowing treatment of diseases and disorders related to expression of Tau, including Alzheimer's disease and primary tauopathies.

  提供了反义寡核苷酸。这些反义寡核苷酸在制备gapmers以抑制Tau mRNA转录方面非常有用。抑制Tau mRNA转录可能导致受试者Tau蛋白质量的降低，从而治疗与Tau表达有关的疾病和疾病，包括阿尔茨海默病和原发性Tau病。
• METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL DISEASES
  申请人：Ophthotech Corporation

  公开号：EP3028707A1

  公开（公告）日：2016-06-08

  This invention relates to methods and compositions useful for the treatment or prevention of an ophthalmological disease, comprising administration of an effective amount of a PDGF antagonist and a VEGF antagonist to a mammal in need thereof.

  本发明涉及用于治疗或预防眼科疾病的方法和组合物，包括向有需要的哺乳动物施用有效量的 PDGF 拮抗剂和 VEGF 拮抗剂。
• PHOTO-SELECTIVE METHOD FOR BIOLOGICAL SAMPLE ANALYSIS FIELD
  申请人：Ventana Medical Systems, Inc.

  公开号：EP3126512A2

  公开（公告）日：2017-02-08
• [EN] FATTY ACID ANTIVIRAL CONJUGATES AND THEIR USES<br/>[FR] CONJUGUÉS ACIDE GRAS ANTIVIRUS ET LEURS UTILISATIONS
  申请人：CATABASIS PHARMACEUTICALS INC

  公开号：WO2013090420A2

  公开（公告）日：2013-06-20

  The invention relates to fatty acid antiviral conjugates; compositions comprising an effective amount of a fatty acid antiviral conjugate; and methods for treating or preventing a a viral infection comprising the administration of an effective amount of a fatty acid antiviral conjugate.