ethyl 2-(aminomethyl)cyclopropane-1-carboxylate | 1000512-53-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-(aminomethyl)cyclopropane-1-carboxylate
• 英文别名: Ethyl 2-(aminomethyl)cyclopropanecarboxylate
• CAS: 1000512-53-7
• 化学式: C₇H₁₃NO₂
• mdl: MFCD09927463
• 分子量: 143.186
• InChiKey: SYDJIQQFQOUGPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2-(aminomethyl)cyclopropane-1-carboxylate 在 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 18.0h， 生成 (2-(((tert-butoxycarbonyl)amino)methyl)cyclopropyl)methyl 4-methylbenzenesulfonate
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS OF TREATING CANCERS
  [FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DE CANCERS

  摘要：

  This disclosure relates to GSPT1 degrader compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds or salts, and methods of making and using the compounds or salts for the treatment of certain diseases. The disclosure also relates to methods for identifying such compounds.

  公开号：

  WO2023193760A1
• 作为产物：
  描述：

  乙基 2-氰基环丙烷-1-羧酸 在 氢气 作用下， 以 甲醇 为溶剂， 以73 %的产率得到ethyl 2-(aminomethyl)cyclopropane-1-carboxylate
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS OF TREATING CANCERS
  [FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DE CANCERS

  摘要：

  This disclosure relates to GSPT1 degrader compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds or salts, and methods of making and using the compounds or salts for the treatment of certain diseases. The disclosure also relates to methods for identifying such compounds.

  公开号：

  WO2023193760A1

文献信息

• PHARMACEUTICAL COMPOUNDS
  申请人：Heptares Therapeutics Limited

  公开号：US20180105491A1

  公开（公告）日：2018-04-19

  This invention relates to compounds that are agonists of the muscarinic M 1 receptor or M 1 and M 4 receptors and which are useful in the treatment of muscarinic M 1 or M 1 /M 4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula wherein Q 4 , Q 5 , R 5 , p, V, Q 1 , Q 2 , X 1 , X 2 and W are defined herein.

  这项发明涉及激动毒蕈碱M1受体或M1和M4受体的化合物，这些化合物在治疗毒蕈碱M1或M1/M4受体介导的疾病中有用。还提供了含有这些化合物的药物组合物以及这些化合物的治疗用途。所提供的化合物的公式如下：其中Q4、Q5、R5、p、V、Q1、Q2、X1、X2和W在此处被定义。
• Renin Inhibitors
  申请人：Baldwin John J.

  公开号：US20090264428A1

  公开（公告）日：2009-10-22

  Described are compounds of the formula (I) which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof.

  本文描述了一种公式（I）的化合物，其具有口服活性并能结合天冬氨酸蛋白酶以抑制其活性。它们可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。还描述了在需要改善或治疗天冬氨酸蛋白酶相关疾病的受试者中使用本文所述化合物的方法。
• RENIN INHIBITORS
  申请人：Baldwin John J.

  公开号：US20090275581A1

  公开（公告）日：2009-11-05

  Disclosed are compounds according to Formula I: wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described herein are methods of antagonizing aspartic protease inhibitors in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound according to Formula I.

  本发明涉及公式I所示的化合物，其中变量在此定义。这些化合物能够结合天冬氨酸蛋白酶以抑制其活性。它们可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。本发明还描述了拮抗需要受到天冬氨酸蛋白酶抑制剂的受试者的方法，包括向受试者施用公式I所示的化合物的治疗有效量。
• Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
  申请人：Heptares Therapeutics Limited

  公开号：US10259787B2

  公开（公告）日：2019-04-16

  This invention relates to compounds that are agonists of the muscarinic M1 receptor or M1 and M4 receptors and which are useful in the treatment of muscarinic M1 or M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula wherein Q4, Q5, R5, p, V, Q1, Q2, X1, X2 and W are defined herein.

  本发明涉及毒蕈碱类 M1 受体或 M1 和 M4 受体的激动剂，可用于治疗毒蕈碱类 M1 或 M1/M4 受体介导的疾病。此外，还提供了含有这些化合物的药物组合物以及这些化合物的治疗用途。所提供的化合物为式 其中 Q4、Q5、R5、p、V、Q1、Q2、X1、X2 和 W 在此定义。
• [EN] COMPOUNDS AND METHODS OF TREATING CANCERS<br/>[FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DE CANCERS
  申请人：[en]CULLGEN (SHANGHAI) , INC.

  公开号：WO2023193760A1

  公开（公告）日：2023-10-12

  This disclosure relates to GSPT1 degrader compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds or salts, and methods of making and using the compounds or salts for the treatment of certain diseases. The disclosure also relates to methods for identifying such compounds.