4,5-bis(4-methoxyphenyl)-β,β-dimethyl-2-thiazoleethanol | 70529-42-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-bis(4-methoxyphenyl)-β,β-dimethyl-2-thiazoleethanol
• 英文别名: 2-(α,α-Dimethyl-β-hydroxyaethyl)-4,5-di-p-anisyl-thiazol；2-[4,5-bis-(4-methoxy-phenyl)-thiazol-2-yl]-2-methyl-propan-1-ol；2-[4,5-Bis(4-methoxyphenyl)-1,3-thiazol-2-yl]-2-methylpropan-1-ol
• CAS: 70529-42-9
• 化学式: C₂₁H₂₃NO₃S
• 分子量: 369.485
• InChiKey: PCGHOARJMZXGSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 4,5-bis(4-methoxyphenyl)-2,2-dimethyl-2-thiazoleacetate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以26%的产率得到4,5-bis(4-methoxyphenyl)-β,β-dimethyl-2-thiazoleethanol
  参考文献：
  名称：

  Synthesis and platelet aggregation inhibitory activity of 4,5-bis(aryl)-2-substituted-thiazoles

  摘要：

  In our continuing effort to discover compound which inhibit collagen-induced platelet aggregation, we have screened compounds in a mouse pulmonary thromboembolism screen. Methyl 4,5-bis(4-methoxyphenyl)-2-thiazoleacetate (3) was very active in the above screen. However, 3 was active for less than 5 min when given orally to guinea pigs. As a result, our synthetic goal was to prepare 2-substituted thiazoles with a much longer duration of activity. This paper describes the preparation of a number 4,5-bis(aryl)-2-substituted-thiazoles and their in vitro and ex vivo activity against collagen-induced platelet aggregation. It was determined that 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)thiazole (16) is the most promising compound.

  DOI：

  10.1021/jm00144a026

文献信息

• RYNBRANDT, R. H.;NISHIZAWA, E. E.;BALOGOYEN, D. P.;MENDOZA, A. R.;ANNIS, +, J. MED. CHEM., 1981, 24, N 12, 1507-1510
  作者：RYNBRANDT, R. H.、NISHIZAWA, E. E.、BALOGOYEN, D. P.、MENDOZA, A. R.、ANNIS, +

  DOI：——

  日期：——
• Synthesis and platelet aggregation inhibitory activity of 4,5-bis(aryl)-2-substituted-thiazoles
  作者：Ronald H. Rynbrandt、Edward E. Nishizawa、Doris P. Balgoyen、A. Rene Mendoza、Kathleen A. Annis

  DOI：10.1021/jm00144a026

  日期：1981.12

  In our continuing effort to discover compound which inhibit collagen-induced platelet aggregation, we have screened compounds in a mouse pulmonary thromboembolism screen. Methyl 4,5-bis(4-methoxyphenyl)-2-thiazoleacetate (3) was very active in the above screen. However, 3 was active for less than 5 min when given orally to guinea pigs. As a result, our synthetic goal was to prepare 2-substituted thiazoles with a much longer duration of activity. This paper describes the preparation of a number 4,5-bis(aryl)-2-substituted-thiazoles and their in vitro and ex vivo activity against collagen-induced platelet aggregation. It was determined that 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)thiazole (16) is the most promising compound.