2-[(tert-butoxy)carbonylamino]-N-{2-[4-oxo-4-piperidyl-2-(3-pyridylcarbonyl)butylthio]ethyl}acetamide | 343578-26-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(tert-butoxy)carbonylamino]-N-{2-[4-oxo-4-piperidyl-2-(3-pyridylcarbonyl)butylthio]ethyl}acetamide
• 英文别名: 2-[(tert-butoxy)carbonylamino]-N-{2-[4-oxo-4-piperidyl-2-(pyridin-3-ylcarbonyl)butylthio]ethyl}acetamide；tert-butyl N-[2-oxo-2-[2-[4-oxo-4-piperidin-1-yl-2-(pyridine-3-carbonyl)butyl]sulfanylethylamino]ethyl]carbamate
• CAS: 343578-26-7
• 化学式: C₂₄H₃₆N₄O₅S
• 分子量: 492.64
• InChiKey: YOIITGUAMFJRCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  34
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  143
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  BOC-甘氨酸 、 2-[(2-aminoethylthio)methyl]-4-piperidyl-1-(3-pyridyl)butane-1,4-dione 、 氯甲酸乙酯 在 三乙胺 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 以35%的产率得到2-[(tert-butoxy)carbonylamino]-N-{2-[4-oxo-4-piperidyl-2-(3-pyridylcarbonyl)butylthio]ethyl}acetamide
  参考文献：
  名称：

  Neuroprotective agents and methods related thereto

  摘要：

  抗神经保护剂的结构如下： 其中R1、R2、R3、R4和R5如本文所定义。这些化合物在治疗通常受益于神经保护剂治疗的疾病方面具有用途，包括治疗中枢和外周神经病症，以及促进神经细胞分化。还公开了治疗这些疾病的方法，以及含有本发明化合物之一或多个的药物组合物。

  公开号：

  US06399606B1

文献信息

• COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION
  申请人：NIPPON KAYAKU CO., LTD.

  公开号：EP1240144A2

  公开（公告）日：2002-09-18
• US6399606B1
  申请人：——

  公开号：US6399606B1

  公开（公告）日：2002-06-04
• [EN] NEUROPROTECTIVE AGENTS AND METHODS RELATED THERETO<br/>[FR] AGENTS NEUROPROTECTEURS ET METHODES ASSOCIEES
  申请人：NIPPON KAYAKU KK

  公开号：WO2001040187A2

  公开（公告）日：2001-06-07

  Neuroprotective agents are disclosed having structure: (I) and stereoisomers and pharmaceutically acceptable salts thereof, wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl or substituted heterocyclealkyl; R2 is -OR2a or -NR2bR2c; R3 is hydrogen, keto, -C(=O)OR3a or -C(=O)NR3bR3c; R4 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, -C(=O)R4a, -C(=O)OR4b, -C(=O)NR4cR4d, -OC(=O)NR4cR4d or -SO2R4c or wherein R3 and R4 taken together form a heterocyclic ring or substituted heterocyclic ring; and R5 is hydrogen, alkyl or substituted alkyl. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.
• Neuroprotective agents and methods related thereto
  申请人：Nippon Kayaku Co., Ltd.

  公开号：US06399606B1

  公开（公告）日：2002-06-04

  Neuroprotective agents are disclosed having the following structure: wherein R1, R2, R3, R4 and R5 are as defined herein. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as for promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.

  抗神经保护剂的结构如下： 其中R1、R2、R3、R4和R5如本文所定义。这些化合物在治疗通常受益于神经保护剂治疗的疾病方面具有用途，包括治疗中枢和外周神经病症，以及促进神经细胞分化。还公开了治疗这些疾病的方法，以及含有本发明化合物之一或多个的药物组合物。