甲基-(2,2,3,3,3-五氟-丙基)-胺 | 425-68-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甲基-(2,2,3,3,3-五氟-丙基)-胺
• 英文名称: Acetat des 3,3,4,4,5,5,5 - Heptafluor-pentan-(1)-ols
• 英文别名: acetic acid-(3,3,4,4,5,5,5-heptafluoro-pentyl ester)；Essigsaeure-(3,3,4,4,5,5,5-heptafluor-pentylester)；3,3,4,4,5,5,5-Heptafluoropentyl acetate；3,3,4,4,5,5,5-heptafluoropentyl acetate
• CAS: 425-68-3
• 化学式: C₇H₇F₇O₂
• 分子量: 256.12
• InChiKey: ZWEZQJCJOMYJJZ-UHFFFAOYSA-N

物化性质

• 沸点：
  137-137.5 °C
• 密度：
  1.4135 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  甲基-(2,2,3,3,3-五氟-丙基)-胺 在 chromium(VI) oxide 、 氢氧化钾 、 氯化亚砜 、 硫酸 、 丙酮 、 二乙二醇 作用下， 生成 2H,2H-heptafluoro-valeryl chloride
  参考文献：
  名称：

  Suicidal behavior—symptom or disorder?

  摘要：

  This article examines the diagnostic status of suicidal ideation with and without additional signs of defined or subthreshold mental disorders. Data from the World Health Organization (WHO) study on Psychological Problems in General Health Care (PPGHC) show that 8.8% of all general practice patients report that they recently had a wish to be dead. Among patients with acute depressive episodes, the rate is 34.5%, as compared with 1.3% in persons without any sign of mental disorder. Rates of suicidal ideation in persons with subthreshold disorders (10.4%) are similar to the rate in persons with other, nondepressed forms of mental disorders (12.9%). Still, 30.1% of all persons with suicidal ideation do not have a defined mental disorder, and 21.5% do not even have subthreshold disorders. But in these persons also, suicidal ideation is associated with an increased rate of depressive complaints. Suicidal ideation therefore, in any case, can be seen as an indicator of mental problems. But it seems impossible to lower the thresholds of defined mental disorders so that all forms of suicidal ideation will be covered. Instead, suicidal thoughts must be regarded as a symptom with the status of a disorder itself which should be handled as a comorbid condition if other mental disorders co-occur, Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1016/s0010-440x(00)80017-6
• 作为产物：
  描述：

  5-acetoxy-1,1,1,2,2,3,3-heptafluoro-5-iodo-pentane 在 盐酸 、 锌 作用下， 以 乙醇 为溶剂， 生成 甲基-(2,2,3,3,3-五氟-丙基)-胺
  参考文献：
  名称：

  Radical Addition of Iodoperfluoroalkanes to Vinyl and Allyl Monomers

  摘要：

  DOI：

  10.1021/jo01056a011

文献信息

• The Synthesis of Fluorine-containing Organosilanes
  作者：O. R. Pierce、E. T. McBee、R. E. Cline

  DOI：10.1021/ja01118a043

  日期：1953.11
• Radical Addition of Iodoperfluoroalkanes to Vinyl and Allyl Monomers
  作者：Neal O. Brace

  DOI：10.1021/jo01056a011

  日期：1962.9
• Suicidal behavior—symptom or disorder?
  作者：B. Ahrens、M. Linden、H. Zäske、H. Berzewski

  DOI：10.1016/s0010-440x(00)80017-6

  日期：2000.3

  This article examines the diagnostic status of suicidal ideation with and without additional signs of defined or subthreshold mental disorders. Data from the World Health Organization (WHO) study on Psychological Problems in General Health Care (PPGHC) show that 8.8% of all general practice patients report that they recently had a wish to be dead. Among patients with acute depressive episodes, the rate is 34.5%, as compared with 1.3% in persons without any sign of mental disorder. Rates of suicidal ideation in persons with subthreshold disorders (10.4%) are similar to the rate in persons with other, nondepressed forms of mental disorders (12.9%). Still, 30.1% of all persons with suicidal ideation do not have a defined mental disorder, and 21.5% do not even have subthreshold disorders. But in these persons also, suicidal ideation is associated with an increased rate of depressive complaints. Suicidal ideation therefore, in any case, can be seen as an indicator of mental problems. But it seems impossible to lower the thresholds of defined mental disorders so that all forms of suicidal ideation will be covered. Instead, suicidal thoughts must be regarded as a symptom with the status of a disorder itself which should be handled as a comorbid condition if other mental disorders co-occur, Copyright (C) 2000 by W.B. Saunders Company.