γGlu-RhoHM | 1241795-10-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γGlu-RhoHM
• 英文别名: (2S)-2-amino-5-[(6'-aminospiro[1H-2-benzofuran-3,9'-xanthene]-3'-yl)amino]-5-oxopentanoic acid
• CAS: 1241795-10-7
• 化学式: C₂₅H₂₃N₃O₅
• 分子量: 445.475
• InChiKey: PFWFFEYVRFHDBS-JINQPTGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  137
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  γGlu-RhoHM 在 γ-glutamyl transpeptidase (GGT; equine kidney, SIGMA G9270-100UN) sodium phosphate 作用下， 以 水 、 二甲基亚砜 为溶剂， 生成 9-(2-hydroxymethylphenyl)-3,6-bisaminoxanthylium
  参考文献：
  名称：

  FLUORESCENT PROBE FOR USE IN MEASUREMENT OF PROTEASE

  摘要：

  公开号：

  EP2399920B1
• 作为产物：
  描述：

  9-(2-hydroxymethylphenyl)-3,6-bisaminoxanthylium 、 Boc-L-谷氨酸-1-叔丁酯 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 、 二氯甲烷 为溶剂， 反应 15.67h， 生成 γGlu-RhoHM
  参考文献：
  名称：

  Fluorescent probe for high-sensitivity pancreatic fluid detection, and method for detecting pancreatic fluid

  摘要：

  下面是表示为以下公式（I）的化合物或其盐的胰液检测用荧光探针。 （在公式中，A代表氨基酸残基或N-取代氨基酸残基，其中A与公式中相邻的NH形成酰胺键；R1代表氢原子或与苯环结合的1至4个相同或不同的取代基团；R2、R3、R4、R5、R6和R7分别独立地代表氢原子、羟基、烷基或卤素原子；R8和R9分别独立地代表氢原子或烷基；X代表C1-C3烷基基团）。

  公开号：

  US09506102B2

文献信息

• Fluorescent probe for high-sensitivity pancreatic fluid detection, and method for detecting pancreatic fluid
  申请人：THE UNIVERSITY OF TOKYO

  公开号：US09506102B2

  公开（公告）日：2016-11-29

  A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R2, R3, R4, R5, R6, and R7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 each independently represent a hydrogen atom or an alkyl group; and X represents a C1-C3 alkylene group).

  下面是表示为以下公式（I）的化合物或其盐的胰液检测用荧光探针。 （在公式中，A代表氨基酸残基或N-取代氨基酸残基，其中A与公式中相邻的NH形成酰胺键；R1代表氢原子或与苯环结合的1至4个相同或不同的取代基团；R2、R3、R4、R5、R6和R7分别独立地代表氢原子、羟基、烷基或卤素原子；R8和R9分别独立地代表氢原子或烷基；X代表C1-C3烷基基团）。
• FLUORESCENT PROBE FOR MEASURING PROTEASE
  申请人：Nagano Tetsuo

  公开号：US20120052518A1

  公开（公告）日：2012-03-01

  A compound represented by the formula (I) or a salt thereof (R 1 represents hydrogen atom, or a substituent; R 2 to R 7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R 8 and R 9 represent hydrogen atom, or an alkyl group; X represents a C 1 -C 3 alkylene group; and R 10 represents an acyl group), which promptly causes a structural change from a non-fluorescent closed ring structure to a strongly fluorescent open ring structure by hydrolysis of an acyl group, and is useful as a fluorescent probe for measuring a protease showing superior suitability for quantification.
• DIAGNOSTIC FOR CANCER
  申请人：Urano Yasuteru

  公开号：US20130023675A1

  公开（公告）日：2013-01-24

  An agent for diagnosing cancer comprising, as an active ingredient, a compound represented by the following formula (I) (R 1 represents hydrogen atom, or a substituent; R 2 to R 7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R 8 and R 9 represent hydrogen atom, or an alkyl group; and X represents a C 1 -C 3 alkylene group), which specifically emits fluorescence in a cancerous tissue within a short time when applied to a part in which presence of a cancerous tissue is suspected.
• US8461358B2
  申请人：——

  公开号：US8461358B2

  公开（公告）日：2013-06-11
• FLUORESCENT PROBE FOR USE IN MEASUREMENT OF PROTEASE
  申请人：The University of Tokyo

  公开号：EP2399920B1

  公开（公告）日：2015-03-25