3-methyl cyclooctanol | 90676-27-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methyl cyclooctanol
• 英文别名: 3-Methyl-cyclooctanol-(1)；3-Methyl-cyclooctanol；3-Methylcyclooctan-1-ol
• CAS: 90676-27-0
• 化学式: C₉H₁₈O
• 分子量: 142.241
• InChiKey: XFOYYVZPDWDTOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-methyl cyclooctanol 生成 3-methylcyclo-octene 、 4-methylcyclo-octene
  参考文献：
  名称：

  Proximity Effects. XXXIV. Solvolysis of cis-Bicyclo[6.1.0]nonane

  摘要：

  DOI：

  10.1021/ja00905a016
• 作为产物：
  描述：

  (Z)-cyclooct-2-enone 在 lithium aluminium tetrahydride 、 copper(l) chloride 作用下， 以 乙醚 为溶剂， 生成 3-methyl cyclooctanol
  参考文献：
  名称：

  Proximity Effects. XXXIV. Solvolysis of cis-Bicyclo[6.1.0]nonane

  摘要：

  DOI：

  10.1021/ja00905a016

文献信息

• PROCESS FOR PREPARATING OPTICALLY ACTIVE COMPOUNDS
  申请人：Japan Science and Technology Corporation

  公开号：EP0916637A1

  公开（公告）日：1999-05-19

  The present invention relates to a novel, highly practical method for producing optically active compounds such as optically active alcohol and optically active amine useful for various utilities such as synthetic intermediates of drugs, liquid crystal materials, and optical resolution agents, comprising hydrogen transfer-type asymmetric reduction in the presence of a transition metal catalyst and an optically active nitrogen-containing compound or a transition metal catalyst with an optically active nitrogen-containing compound as the asymmetric ligand, and a hydrogen-donating organic or inorganic compound. In accordance with the present invention, characteristically, an optically active secondary alcohol can be recovered through the hydrogen transfer-type oxidation from racemic secondary alcohol or meso-type diol.

  本发明涉及一种生产光学活性化合物（如光学活性醇和光学活性胺）的新型、高度实用的方法，该方法可用于药物合成中间体、液晶材料和光学分辨剂等多种用途，包括在过渡金属催化剂和光学活性含氮化合物或过渡金属催化剂与光学活性含氮化合物作为不对称配体以及供氢有机或无机化合物存在下进行氢转移型不对称还原。 根据本发明，外消旋仲醇或中型二元醇通过氢转移型氧化可回收光学活性仲醇。
• PROCESSES FOR THE PREPARATION OF OPTICALLY ACTIVE KETONES
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0924180A1

  公开（公告）日：1999-06-23

  Disclosed herein are a process for producing an optically active ester by reaction of a racemic alcohol with an optically active amino acid derivative or optically active tartaric acid derivative, a process for producing an optically active alcohol by hydrolysis of said optically active ester, a process for converting an alcohol into a ketone by oxidation, a method for stably storing an optically active ketone, and a new optically active amino acid ester and a new optically active tartaric acid ester. These compounds are important as intermediates for medicines and agricultural chemicals.

  本文公开了一种通过外消旋醇与光学活性氨基酸衍生物或光学活性酒石酸衍生物反应生产光学活性酯的工艺、一种通过水解所述光学活性酯生产光学活性醇的工艺、一种通过氧化将醇转化为酮的工艺、一种稳定储存光学活性酮的方法，以及一种新的光学活性氨基酸酯和一种新的光学活性酒石酸酯。这些化合物是重要的医药和农药中间体。
• PROCESS FOR PRODUCING ALDEHYDE COMPOUND OR KETONE COMPOUND WITH USE OF MICROREACTOR
  申请人：Ube Industries, Ltd.

  公开号：EP1710223B1

  公开（公告）日：2012-10-31
• Process for preparing optically active alcohols
  申请人：Japan Science and Technology Agency

  公开号：EP1300381B1

  公开（公告）日：2006-03-08
• Method for producing aldehyde compound or ketone compound by using microreactor
  申请人：Ataka Kikuo

  公开号：US20070149823A1

  公开（公告）日：2007-06-28

  The method for producing an aldehyde or ketone compound from a corresponding primary or secondary alcohol at relatively high temperature within a short time with a high yield including a step (1) of reacting a sulfoxide compound with an activating agent to produce an activation reaction product; a step (2) of reacting the activation reaction product with a primary or secondary alcohol to produce an alkoxysulfonium salt; and a step (3) of reacting the reaction product with a base to produce an aldehyde or ketone; wherein at least one of the steps, preferably the step (1) and step (2), are carried out by using a microreactor.