methyl 2-methylglycerate | 130427-16-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2-methylglycerate
• 英文别名: 3-hydroxy-2-methoxy-propionic acid methyl ester；3-Hydroxy-2-methoxy-propionsaeure-methylester；2-O-Methyl-DL-glycerinsaeure-methylester；Methyl 3-hydroxy-2-methoxypropanoate
• CAS: 130427-16-6
• 化学式: C₅H₁₀O₄
• 分子量: 134.132
• InChiKey: UTPJJERSMZYBEY-UHFFFAOYSA-N

物化性质

• 沸点：
  95 °C(Press: 10 Torr)
• 密度：
  1.129±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-methylglycerate 生成 2-methylglycerol
  参考文献：
  名称：

  Hydrogenation of alkoxy-substituted esters and products

  摘要：

  公开号：

  US02321608A1
• 作为产物：
  描述：

  2-甲氧基-3-氧代丙酸甲酯 在 水 、 镍 作用下， 50.0 ℃ 、3.92 MPa 条件下， 生成 methyl 2-methylglycerate
  参考文献：
  名称：

  Baker, Journal of the Chemical Society, 1942, p. 521

  摘要：

  DOI：

文献信息

• Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof
  申请人：XDCEXPLORER (SHANGHAI) CO., LTD.

  公开号：US10449258B2

  公开（公告）日：2019-10-22

  Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.

  披露了一种抗体药物偶联物IB，它使用醚键连接，提高了体内和体外的水溶性、稳定性和细胞毒性，以及一种中间体、药物组合物和抗体药物偶联物的用途。该抗体药物偶联物具有简单的合成步骤和高产率。
• Modulators of peroxisome proliferator activated receptors
  申请人：Brooks Alisa Dawn

  公开号：US20050020684A1

  公开（公告）日：2005-01-27

  Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH 2 — or —CH 2 CH 2 —; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R 1 and W, R 2 is (CH 2 ) n —CH(OR 2 )—(CH 2 ) n E, —(CH)═C(OR 2 )—(CH 2 ) n E, —(CH 2 ) n —CH(Y)—(CH 2 ) m E or (CH)═C(Y)(CH 2 ) m E; wherein E is COOR 3 , C 1 -C 3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C 1 -C 6 alkyl, haloalkyl and aryl-C o - 4 -alkyl; R 2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR 4 , —COOR 4 , —CONR 5 R 6 , —C(S)R 4 , —C(S)OR 4 or C(S)NR 5 R 6 , R 3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH 2 —, CH 2 CH 2 — or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R 1 . R 4 -R 6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.

  本发明公开了一种由结构式（I）表示的化合物：其中Ar是取代或未取代的芳香基团。Q是共价键，-CH2-或-CH2CH2-; W是取代或未取代的烷基或取代或未取代的异烷基连接基，长度为两到十个原子，优选长度为两到七个原子。苯环A可选地与R1和W以外的最多四个取代基取代，R2是（CH2）n-CH（OR2）-（CH2）nE，-（CH）=C（OR2）-（CH2）nE，-（CH2）n-CH（Y）-（CH2）mE或（CH）=C（Y）（CH2）mE;其中E是COOR3，C1-C3烷基腈，羧酰胺，磺酰胺，酰基磺酰胺或四唑，磺酰胺，酰基磺酰胺和四唑可选地与一个或多个取代基取代，独立地选自：C1-C6烷基，卤代烷基和芳基-Co-4-烷基; R2是H，脂肪基，取代脂肪基，卤代烷基，芳基，取代芳基，-COR4，-COOR4，-CONR5R6，-C（S）R4，-C（S）OR4或C（S）NR5R6，R3是H，脂肪基，取代脂肪基，芳基或取代芳基。Y是O-，CH2-，CH2CH2-或CH═CH-，并与Phenyl环A中与R1相邻的碳原子键合。R4-R6独立地是H，脂肪基，取代脂肪基，芳基或取代芳基。n和m独立地为0、1或2。
• DE708623
  申请人：——

  公开号：——

  公开（公告）日：——
• DE729187
  申请人：——

  公开号：——

  公开（公告）日：——
• Process for producing oxycarboxylic acid esters
  申请人：CONSORTIUM ELEKTROCHEM IND

  公开号：US02208355A1

  公开（公告）日：1940-07-16