2-(p-amino-phenoxy)-propionic acid | 78547-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(p-amino-phenoxy)-propionic acid
• 英文别名: 2-(4-amino-phenoxy)-propionic acid；α-(4-Amino-phenoxy)-propionsaeure；2-(4-Amino-phenoxy)-propionsaeure；2-(4-Aminophenoxy)propanoic acid
• CAS: 78547-13-4
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: VJYRXSCKENWETD-UHFFFAOYSA-N

物化性质

• 熔点：
  193-196 °C
• 沸点：
  363.8±17.0 °C(Predicted)
• 密度：
  1.260±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(p-amino-phenoxy)-propionic acid 在 硫酸 、 氢气 、 镍 、 sodium carbonate 、 copper(II) sulfate 、 sodium nitrite 作用下， 以 ammonium hydroxide 为溶剂， 反应 28.25h， 生成 ethyl 2--propionate
  参考文献：
  名称：

  Biagi; Livi; Scartoni, Farmaco, Edizione Scientifica, 1988, vol. 43, # 7-8, p. 597 - 611

  摘要：

  DOI：
• 作为产物：
  描述：

  2-苯氧基丙酸 生成 2-(p-amino-phenoxy)-propionic acid
  参考文献：
  名称：

  Bischoff, Chemische Berichte, 1900, vol. 33, p. 930

  摘要：

  DOI：

文献信息

• 2,4-Pyrimidinediamine Compounds and Their Uses
  申请人：Singh Rajinder

  公开号：US20150266828A1

  公开（公告）日：2015-09-24

  The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

  本发明提供了抑制IgE和/或IgG受体信号级联反应的2,4-嘧啶二胺化合物，该级联反应导致化学介质的释放，以及合成这些化合物的中介体和方法，以及在多种情况下使用这些化合物的方法，包括在治疗和预防由脱粒和其他由IgE和/或IgG受体信号级联反应激活引起的化学介质释放所表征、引起或相关的疾病。
• Functionalized drugs and polymers derived therefrom
  申请人：Bezwada S. Rao

  公开号：US20060172983A1

  公开（公告）日：2006-08-03

  Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH 2 are biologically active compounds; each X is independently selected from —CH 2 COO— (glycolic acid moiety), —CH(CH 3 )COO— (lactic acid moiety), —CH 2 CH 2 OCH 2 COO— (dioxanone moiety), —CH 2 CH 2 CH 2 CH 2 CH 2 COO— (caprolactone moiety), —(CH 2 ) y COO—, where y is 2-4 or 6-24 and —(CH 2 CH 2 O) z CH 2 COO—, where z is 2-24; each Y is independently selected from —COCH 2 O— (glycolic ester moiety), —COCH(CH 3 )O— (lactic ester moiety), —COCH 2 OCH 2 CH 2 O— (dioxanone ester moiety), —COCH 2 CH 2 CH 2 CH 2 CH 2 O— (caprolactone ester moiety), —CO(CH 2 ) m O—, where m is 2-4 or 6-24 and —COCH 2 O(CH 2 CH 2 O) n — where n is between 2-24; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.

  从中选择的化合物：其中DRUG-OH，DRUG-COOH和DRUG-NH2是生物活性化合物；每个X独立地从—CH2COO—（乙二酸基团），—CH(CH3)COO—（乳酸基团），—CH2CH2OCH2COO—（二氧杂环己酮基团），—CH2CH2CH2CH2CH2COO—（己内酯基团），—(CH2)yCOO—中选择，其中y为2-4或6-24和—(CH2CH2O)zCH2COO—，其中z为2-24；每个Y独立地从—COCH2O—（乙二酸酯基团），—COCH(CH3)O—（乳酸酯基团），—COCH2OCH2CH2O—（二氧杂环己酮酯基团），—COCH2CH2CH2CH2CH2O—（己内酯酯基团），—CO(CH2)mO—，其中m为2-4或6-24和—COCH2O(CH2CH2O)n—，其中n为2-24；R′为氢，苄基或烷基，烷基可以是直链或支链；p为1-6。还披露了多功能化合物和药物二聚体、寡聚体和聚合物。
• FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20090170927A1

  公开（公告）日：2009-07-02

  The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X) p —R′] q I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

  本发明涉及公式I的化合物，这些化合物是官能化酚类化合物，以及由它们形成的聚合物。从官能化酚类化合物形成的聚合物预计具有可控的降解特性，使它们能够在所需的时间范围内释放活性成分。这些聚合物还预计在各种医疗应用中有用。
• Functionalized phenolic esters and amides and polymers therefrom
  申请人：Bezwada S. Rao

  公开号：US20060173065A1

  公开（公告）日：2006-08-03

  The present invention relates to a compound of the formula: R-AR—O—Y—R′ Wherein R represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid, —NO 2 , —NH 2 , —NHCOCH 3 , and —NH—Y—R′, which is attached directly to AR or attached through an aliphatic chain. The carboxylic acid moiety in R includes but is not limited to the following carboxylic acids: benzoic acids, cinnamic acids, ferulic acid, caffeic acid, syringic acid, salicylic acid, vanillic acid, phenylacetic acids, phenylpropionic acids, and sinapinic acid. -AR—O— is a biologically active phenolic moiety comprising 1 to 6 substituted or unsubstituted aryl rings that are directly bonded to each other, fused together, or joined through a linking group. Y represents a member selected from: —COCH 2 O— (glycolic ester moiety) —COCH(CH 3 )O— (lactic ester moiety) —COCH 2 OCH 2 CH 2 O— (dioxanone ester moiety) —COCH 2 CH 2 CH 2 CH 2 CH 2 O— (caprolactone ester moiety) —CO(CH 2 ) m O— where m is an integer between 2-4 and 6-24 inclusive —COCH 2 O(CH 2 CH 2 O) n — where n is an integer between 2 and 24, inclusive; and R′ is either hydrogen or a benzyl or an alkyl group, the alkyl group being either straight-chained or branched. The resultant functionalized phenolic compounds, used singly or in combinations, and their polymers have controllable degradation profiles, releasing the active component over a desired time range. The polymers are useful for biomaterials and biomedical devices, wherein said biologically active phenolic moiety is a residue of a phenolic compound.

  本发明涉及一种化合物，其化学式为：R-AR—O—Y—R′，其中R代表从H、烷氧基、苯甲氧基、醛基、卤素、羧酸、—NO2、—NH2、—NHCOCH3和—NH—Y—R′中选择的一个或多个成员，该成员直接附着在AR上或通过脂肪链连接。R中的羧酸基团包括但不限于以下羧酸：苯甲酸、肉桂酸、阿魏酸、咖啡酸、槲皮酸、水杨酸、香草酸、苯乙酸、苯丙酸和芥子酸。-AR—O—是一个生物活性的酚基团，包括1到6个取代或未取代的芳香环直接连接、融合或通过连接基团连接的环。Y代表从以下成员中选择：—COCH2O—（乙二醇酯基团）—COCH(CH3)O—（乳酸酯基团）—COCH2OCH2CH2O—（二氧环酮酯基团）—COCH2CH2CH2CH2CH2O—（己内酯酯基团）—CO(CH2)mO—其中m是2-4和6-24之间的整数—COCH2O(CH2CH2O)n—其中n是2到24之间的整数；R′是氢或苄基或烷基，烷基可以是直链或支链。所得的功能化酚类化合物单独或组合使用，其聚合物具有可控的降解特性，释放所需时间范围内的活性成分。该聚合物对于生物材料和生物医学器械有用，其中所述的生物活性酚基团是酚类化合物的残留物。
• Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices
  申请人：S. Bezwada Rao

  公开号：US20060188547A1

  公开（公告）日：2006-08-24

  Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH 2 COO— (glycolic acid moiety), —CH(CH 3 )COO— (lactic acid moiety), —CH 2 CH 2 OCH 2 COO— (dioxanone), —CH 2 CH 2 CH 2 CH 2 CH 2 COO— (caprolactone moiety), —(CH 2 ) y COO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH 2 CH 2 O) z′ CH 2 COO— where z′ is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH 2 O— (glycolic ester moiety), —COCH(CH 3 )O— (lactic ester moiety), —COCH 2 OCH 2 CH 2 O— (dioxanone ester), —COCH 2 CH 2 CH 2 CH 2 CH 2 O— (caprolactone ester), —CO(CH 2 ) m O— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH 2 O(CH 2 CH 2 O) n — where n is an integer between 2 and 24, inclusive; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO 2 , which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.

  由至少选择自以下化合物制备的可吸收聚氨酯、聚酰胺和聚酯聚氨酯：或其二胺和二异氰酸酯，其中每个X分别代表从—CH2COO—（乙二醇酸基团），—CH（CH3）COO—（乳酸酸基团），—CH2CH2OCH2COO—（二氧环己酮），—CH2CH2CH2CH2CH2COO—（己内酯基团），—（CH2）yCOO—其中y是2、3、4或6-24之间的一个数字，以及—（CH2CH2O）z′CH2COO—其中z′是介于2和24之间的整数；每个Y分别代表从—COCH2O—（乙二醇酸酯基团），—COCH（CH3）O—（乳酸酸酯基团），—COCH2OCH2CH2O—（二氧环己酮酯基团），—COCH2CH2CH2CH2CH2O—（己内酯酯基团），—CO（CH2）mO—其中m是介于2、3、4或6-24之间的整数，—COCH2O（CH2CH2O）n—其中n是介于2和24之间的整数；R′是氢、苄基或烷基，烷基可以是直链或支链；p是介于1和4之间的整数；Rn代表选择自H、烷氧基、苯甲氧基、醛、卤素、羧酸和—NO2的一个或多个成员，它直接附着在芳香环上或通过脂肪链附着。从这些化合物制备的可吸收聚合物对于药物传递、组织工程、组织粘接、粘着预防和其他可植入医疗器械非常有用。