2,3,6-Tri-O-benzyl-D-glucopyranose | 24679-79-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3,6-Tri-O-benzyl-D-glucopyranose
• 英文别名: (2S,3R,4S,5S,6R)-3,4-bis(phenylmethoxy)-6-(phenylmethoxymethyl)oxane-2,5-diol
• CAS: 24679-79-6
• 化学式: C₂₇H₃₀O₆
• 分子量: 450.532
• InChiKey: LEDXJBXNRDUCKA-KQZFZZGISA-N

物化性质

• 沸点：
  622.7±55.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,3,6-Tri-O-benzyl-D-glucopyranose 、 盐酸 、 乙醚 以76%的产率得到
  参考文献：
  名称：

  SATO, TOSHIHIKO;NAKAMURA, HIROYUKI;OHNO, YASUO;ENDO, TAKESHI, CARBOHYDR. RES., 199,(1990) N, C. 31-35

  摘要：

  DOI：
• 作为产物：
  描述：

  (1R,3R,5R,6R,8R,10R,11R,13R,15R,16R,18R,20R,21R,23R,25R,26R,28R,30R,31R,33R,35R,36S,37R,38S,39R,40S,41R,42S,43R,44S,45R,46S,47R,48S,49R)-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecakis(phenylmethoxy)-5,10,15,20,25,30,35-heptakis(phenylmethoxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane 、 硫酸 生成 2,3,6-Tri-O-benzyl-D-glucopyranose
  参考文献：
  名称：

  SATO, TOSHIHIKO;NAKAMURA, HIROYUKI;OHNO, YASUO;ENDO, TAKESHI, CARBOHYDR. RES., 199,(1990) N, C. 31-35

  摘要：

  DOI：

文献信息

• Novel alpha-glucosidase inhibitors
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0389723A1

  公开（公告）日：1990-10-03

  This invention relates to novel N-derivatives, of 1,4-di-­deoxy-1,4-imino-L-arabinitol (I), to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes. wherein n is zero, one or two, and R is a glycosyl or etherified or acylated glycosyl radical containing from 1 to 3 hexose or pentose units, said glycosyl radical optionally bearing an ether or ester derivative of the hydroxyl moiety located on the anomeric carbon atom.

  本发明涉及新颖的1,4-二脱氧-1,4-亚氨基-L-阿拉伯糖醇（I）的N-衍生物，涉及其制备方法及其最终用途，特别是作为治疗糖尿病的用途。 其中n为0、1或2，R为含有1至3个己糖或戊糖单元的糖基或醚化或酰化的糖基基团，所述糖基基团任选地在其异头碳原子上的羟基部分带有醚或酯衍生物。
• [EN] VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE SEROTYPE 8<br/>[FR] VACCINS CONTRE STREPTOCOCCUS PNEUMONIAE SÉROTYPE 8
  申请人：MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V

  公开号：WO2016046420A1

  公开（公告）日：2016-03-31

  The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcuspneumoniae serotype 8 capsular polysaccharide, conjugates thereof and the use of said saccharides and conjugates for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide structures of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcuspneumoniae bacteria.

  本发明涉及一般式（I）的合成糖苷，与肺炎链球菌8型蒽聚糖有关，以及它们的结合物，以及利用所述糖苷和结合物在人类和/或动物宿主中引发保护性免疫反应。此外，一般式（I）的合成糖苷结构可用作免疫学检测中的标记，用于检测针对肺炎链球菌细菌的抗体。
• Novel alpha-Glucosidase inhibitors
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0344383A1

  公开（公告）日：1989-12-06

  This invention relates to novel N-derivatives of 1-deoxy-nojirimyoin, to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes.

  本发明涉及 1-脱氧野尻yoin的新型 N-衍生物、其制备工艺及其最终用途，特别是在治疗糖尿病方面的应用。
• Novel Alpha-glucosidase inhibitors
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0345104A2

  公开（公告）日：1989-12-06

  This invention relates to novel N-derivatives of 1-deoxy-nojirimycin (1) to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes. wherein n is zero, one or two, and R is a glycosyl or etherified or acylated glycosyl radical containing from 1 to 3 hexose or pentose units, said glycosyl radical optionally bearing an ether or ester derivative of the hydroxyl moeity located on the anomeric carbon atom of the terminal hexose or pentose moeity.

  本发明涉及 1-脱氧-野尻霉素（1）的新型 N 衍生物及其制备工艺和最终应用，特别是在糖尿病治疗中的应用。 其中 n 为 0、1 或 2，R 为含有 1 至 3 个己糖或戊糖单元的糖基或醚化或酰化的糖基，所述糖基任选带有位于末端己糖或戊糖单元的异构碳原子上的羟基的醚或酯衍生物。
• Synthetic vaccines against Streptococcus pneumoniae serotype 8
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3000820A1

  公开（公告）日：2016-03-30

  The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcus pneumoniae serotype 8 capsular polysaccharide, conjugates thereof and the use of said saccharides and conjugates for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide structures of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.

  本发明涉及与肺炎链球菌血清型 8 荚膜多糖有关的通式（I）合成糖、其共轭物以及使用所述糖和共轭物在人和/或动物宿主中提高保护性免疫反应。此外，通式（I）的合成糖结构可作为免疫学试验中的标记物，用于检测针对肺炎链球菌的抗体。