5-formyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid | 124523-12-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-formyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid
• 英文别名: 5-formyl-2-(4-methyl-5-oxo-4-propan-2-yl-1H-imidazol-2-yl)pyridine-3-carboxylic acid
• CAS: 124523-12-2
• 化学式: C₁₄H₁₅N₃O₄
• 分子量: 289.291
• InChiKey: WGSWIDZDULIQTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-formyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid 、 、 1,2-丙二醇 、 对甲苯磺酸 在 二氯甲烷 、 水 、 Brine 、 magnesium sulfate 、 甲醇 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以to yield the title compound as a yellow solid (0.5 g, 74%), mp 50°-52° C.的产率得到5-(4-Methyl-1,3-dioxolan-2-yl)-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid
  参考文献：
  名称：

  5-heterocyclic 2-(2-imidazolin-2-yl)-pyridines as herbicides

  摘要：

  本文描述了由公式II和III所代表的5-杂环2-(2-咪唑啉-2-基)吡啶化合物，对于控制不良植物物种具有有效性。同时还描述了一种使用该化合物进行除草的方法。

  公开号：

  US05283230A1
• 作为产物：
  描述：

  5-Dimethoxymethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid 、 碳酸氢钠 在 Acetone ethanol 作用下， 以 盐酸 为溶剂， 反应 20.0h， 以to obtain 5-formyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid, fourth hapten的产率得到5-formyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid
  参考文献：
  名称：

  Functionalized imidazolinone haptens and protein conjugates thereof

  摘要：

  本发明提供了酶偶联物、抗原、抗体和诊断试剂盒，用于酶联免疫吸附测定法测定咪唑烷类化合物的存在和浓度。

  公开号：

  US05342771A1

文献信息

• 5-heterocyclic 2-(2-imidazolin-2-yl)pyridines, useful as herbicidal
  申请人：American Cyanamid Company

  公开号：US05405827A1

  公开（公告）日：1995-04-11

  5-Heterocyclic 2-(2-imidazolin-2-yl)pyridine compounds which are effective for the control of undesirable plant species are described. Also described are a method for the herbicidal use of said compounds and a method for their preparation.

  本发明涉及5-杂环2-(2-咪唑啉-2-基)吡啶化合物，该化合物对于控制不良植物物种具有良好的效果。同时还提供了一种利用该化合物进行除草的方法和一种制备该化合物的方法。
• Novel 5(and/or 6)substituted 2-(2-imidazolin-2-yl)nicotinic acids, esters and salts, useful as herbicidal agents and nivel intermediates for the preparation of said nicotinic acids, esters and salts
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0322616A2

  公开（公告）日：1989-07-05

  There are provided novel 5(and/or 6)substituted 2-(2-imidazolin-2-yl) and 2-(2-imidazolidinyl)nicotinic acids, esters and salts, which are useful as herbicidal agents. There are also provided novel substituted pyrrolopyridine acetonitriles, pyrrolopyridine acetamides, imidazopyrrolopyridinediones and carbamoylnicotinic acid esters, that are useful as intermediates for the preparation of the above said herbicidal agents.

  提供了新型 5(和/或 6)取代的 2-(2-咪唑啉-2-基)和 2-(2-咪唑啉基)烟酸、酯和盐，可用作除草剂。此外，还提供了新型取代的吡咯并吡啶乙腈、吡咯并吡啶乙酰胺、咪唑并吡啶二酮和氨基甲酰基烟酸酯，可用作制备上述除草剂的中间体。
• Alkyl esters of 5-heterocyclic-pyridine-2,3-dicarboxylic acids and 5-heterocyclic 2-(2-imidazolin-2-yl) pyridines and methods for preparation thereof
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0434965A2

  公开（公告）日：1991-07-03

  There are provided alkyl esters of 5-heterocyclic-pyridine-2,3-dicarboxylic acids and 5-heterocyclic 2-(2-imidazolin-2-yl)pyridine compounds, which are effective for the control of undesirable plant species. Also described are methods for the herbicidal use of said compounds and methods for their preparation.

  本发明提供了 5-杂环吡啶-2,3-二羧酸的烷基酯和 5-杂环 2-(2-咪唑啉-2-基)吡啶化合物，它们可有效控制不良植物物种。此外，还介绍了上述化合物的除草方法及其制备方法。
• AHAS inhibiting herbicide resistant wheat and method for selection thereof
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0508161A1

  公开（公告）日：1992-10-14

  This invention is directed to a screening method for the selection of mutations which confer acetohydroxyacid synthase (AHAS) inhibiting herbicide resistance to wheat. After mutagenesis of wheat seeds, the seeds are soaked in an AHAS inhibiting herbicide-containing solution containing a particular class of AHAS inhibiting herbicide. After planting, the soil containing the seeds is sprayed with an AHAS inhibiting herbicide of the same class as that used in the seed soak step prior to the emergence of the seedlings from the soil. Those wheat seedlings which emerge and are normal in appearance demonstrate resistance to the class of AHAS inhibiting herbicides used in the seed soak and spraying steps. This invention is also directed to the wheat selections and seeds identified by the screening method.

  本发明涉及一种筛选方法，用于选择使小麦具有乙酰羟基酸合成酶（AHAS）抑制除草剂抗性的突变。诱变小麦种子后，将种子浸泡在含有 AHAS 抑制性除草剂的溶液中，该溶液含有特定类别的 AHAS 抑制性除草剂。播种后，在秧苗出土前，在含有种子的土壤中喷洒与浸种步骤中使用的同类 AHAS 抑制除草剂。出苗且外观正常的麦苗对浸种和喷洒步骤中使用的 AHAS 抑制除草剂具有抗性。本发明还涉及通过筛选方法确定的小麦品种和种子。
• Oxime derivatives of formylpyridyl imidazolinones, the herbicidal us and methods for the preparation thereof
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0539676A1

  公开（公告）日：1993-05-05

  This disclosure describes new 5-oximio-2-(2-imidazolin-2-yl) pyridines having the following structure: wherein Y is hydrogen, C₁-C₄ branched or unbranched alkyl optionally substituted with C₁-C₄ alkoxy, C₁-C₄ alkylthiol, halogen, CO₂R₄, CN, NHCOR₅, OCOR₄, furyl or a phenyl group optionally substituted with one or two halogens, C₁-C₂ alkyl or nitro, C₁-C₄ alkenyl optionally substituted with halogen or C₁-C₄ alkoxy, or C₁-C₄ alkynyl; and Z is hydrogen or C₁-C₄ alkyl. The disclosure further describes the unique method of using the compounds as herbicidal agents and the methods for their preparation.

  本公开介绍了具有以下结构的新型 5-氧亚氨基-2-(2-咪唑啉-2-基)吡啶： 其中 Y 是氢、任选被 C₁-C₄ 烷氧基、C₁-C₄ 烷硫醇、卤素、CO₂R₄、CN、NHCOR₅、OCOR₄、呋喃基或任选被一个或两个卤素、C₁-C₂ 烷基或硝基取代的苯基、任选被卤素或 C₁-C₄ 烷氧基取代的 C₁-C₄ 烯基或 C₁-C₄ 烷炔基；Z 是氢或 C₁-C₄ 烷基。本公开进一步描述了将这些化合物用作除草剂的独特方法及其制备方法。