N-(2-fluorophenyl)-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide | 879178-93-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-fluorophenyl)-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide
• 英文别名: NCGC00186540；N-(2-fluorophenyl)-2-oxo-3,4-dihydro-1H-quinoline-6-sulfonamide
• CAS: 879178-93-5
• 化学式: C₁₅H₁₃FN₂O₃S
• 分子量: 320.344
• InChiKey: FXULHVBWXADQIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氟苯胺 、 1,2,3,4-四氢-2-氧代-6-喹啉磺酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以61.3 %的产率得到N-(2-fluorophenyl)-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide
  参考文献：
  名称：

  芳基磺酰胺化合物及其用途

  摘要：

  本发明涉及如本申请所定义的式(I)的芳基磺酰胺化合物、其制备方法、包含或基于所述化合物的PROTAC分子、包含所述化合物或PROTAC分子的药物组合物及其用于预防或治疗CRBN相关疾病或病症的用途。

  公开号：

  CN115572259A

文献信息

• [EN] ACTIVATORS OF HUMAN PYRUVATE KINASE<br/>[FR] ACTIVATEURS DE LA PYRUVATE KINASE HUMAINE
  申请人：US HEALTH

  公开号：WO2011137089A1

  公开（公告）日：2011-11-03

  Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A1, A2, L, R, R1 to R3, X1 to X3, k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A1 -NR-L-A2 (I)

  公开了一些丙酮酸激酶M2激活剂，这些激活剂是化合物式(I)的化合物，包括化合物式(II)，其中A1、A2、L、R、R1至R3、X1至X3、k、n和m的定义如下，在治疗通过激活PKM2可治疗的多种疾病中有用，例如癌症。 A1 -NR-L-A2 (I)
• ACTIVATORS OF HUMAN PYRUVATE KINASE
  申请人：Boxer Matthew B.

  公开号：US20130109672A1

  公开（公告）日：2013-05-02

  Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A 1 , A 2 , L, R, R 1 to R 3 , X 1 to X 3 , k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A 1 -NR-L-A 2 (I).

  本发明涉及一种丙酮酸激酶M2活化剂，包括式(I)中的化合物，其中包括式(II)中的化合物，其中A1、A2、L、R、R1到R3、X1到X3、k、n和m的定义如本文所述，这些化合物可用于治疗许多可通过激活PKM2来治疗的疾病，例如癌症。其中，A1-NR-L-A2(I)。
• 芳基磺酰胺化合物及其用途
  申请人：四川科伦博泰生物医药股份有限公司

  公开号：CN115572259A

  公开（公告）日：2023-01-06

  本发明涉及如本申请所定义的式(I)的芳基磺酰胺化合物、其制备方法、包含或基于所述化合物的PROTAC分子、包含所述化合物或PROTAC分子的药物组合物及其用于预防或治疗CRBN相关疾病或病症的用途。
• US9708267B2
  申请人：——

  公开号：US9708267B2

  公开（公告）日：2017-07-18
• 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
  作者：Martin J. Walsh、Kyle R. Brimacombe、Henrike Veith、James M. Bougie、Thomas Daniel、William Leister、Lewis C. Cantley、William J. Israelsen、Matthew G. Vander Heiden、Min Shen、Douglas S. Auld、Craig J. Thomas、Matthew B. Boxer

  DOI：10.1016/j.bmcl.2011.08.114

  日期：2011.11

  Compared to normal differentiated cells, cancer cells have altered metabolic regulation to support biosynthesis and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this anabolic metabolism. While the M1 isoform is a highly active enzyme, the alternatively spliced M2 variant is considerably less active and expressed in tumors. While the exact mechanism by which decreased pyruvate kinase activity contributes to anabolic metabolism remains unclear, it is hypothesized that activation of PKM2 to levels seen with PKM1 may promote a metabolic program that is not conducive to cell proliferation. Here we report the third chemotype in a series of PKM2 activators based on the 2-oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamide scaffold. The synthesis, structure activity relationships, selectivity and notable physiochemical properties are described. Published by Elsevier Ltd.