1,7-Dioxaspiro[5.5]undec-3-ene | 147274-32-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,7-Dioxaspiro[5.5]undec-3-ene
• CAS: 147274-32-6
• 化学式: C₉H₁₄O₂
• 分子量: 154.21
• InChiKey: WPXSZYFCILXAAQ-UHFFFAOYSA-N

物化性质

• 沸点：
  231.3±40.0 °C(Predicted)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Compositions and methods for the treatment of hypertension
  申请人：Zamir Nadav

  公开号：US20050272808A1

  公开（公告）日：2005-12-08

  The present invention relates to use of 1,7-dioxaspiro[5.5]undecane and derivatives thereof for the preparation of a medicament for the treatment or prevention of hypertension. The invention also provides a method for treatment or prevention of hypertension using a medicament comprising 1,7-dioxaspiro[5.5]undecane or a derivative thereof as an active ingredient, such that the hypertension is treated or prevented, as the case may be.
• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF MALE ERECTILE DYSFUNCTION (ED)<br/>[FR] COMPOSITIONS ET PROCEDES POUR LE TRAITEMENT DE DYSFONCTIONNEMENT DE L'ERECTION
  申请人：DARLEY PHARMACUETICALS LTD

  公开号：WO2007004226A2

  公开（公告）日：2007-01-11

  [EN] The present invention relates to use of 1,7-dioxaspiro[5.5]undecane and related compounds of the general formula (I) for the preparation of a pharmaceutical composition for the treatment or prevention of erectile dysfunction (ED). The invention further provides a method for the treatment or prevention of ED by administering 1,7?dioxaspiro[5.5]undecane or a related compound of the general formula (I) as an active ingredient, thereby treating and/or preventing ED.
  [FR] Utilisation de 1,7-dioxaspiro[5.5]undécane et de composés connexes de formule générale (I) pour l'élaboration de composition pharmaceutique intervenant dans le traitement ou la prévention de dysfonctionnement de l'érection, et procédés correspondants qui reposent sur l'administration de 1,7dioxaspiro[5.5]undécane ou de composé connexe de formule générale (I) comme principe actif, pour le traitement et/ou la prévention de l'affection considérée.^.