4-Pyrrol-1-ylheptanoic acid | 1258963-07-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Pyrrol-1-ylheptanoic acid
• CAS: 1258963-07-3
• 化学式: C₁₁H₁₇NO₂
• 分子量: 195.261
• InChiKey: ABLQNVUPWLFIOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Pyrrol-1-ylheptanoic acid 在 polyphosphoric acid 作用下， 反应 0.5h， 以80%的产率得到5-propyl-6,7-dihydro-5H-indolizin-8-one
  参考文献：
  名称：

  Straightforward synthesis of indolizidine alkaloid 167B

  摘要：

  The synthetic access to indolizidines, substituted in C-5 position, was reported with good diastereoselectivity. The strategy developed was based on a key step of Michael addition associated with a Clauson-Kaas condensation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.105
• 作为产物：
  描述：

  2,5-二甲氧基四氢呋喃 、 4-amino-heptanoic acid 在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以73%的产率得到4-Pyrrol-1-ylheptanoic acid
  参考文献：
  名称：

  Straightforward synthesis of indolizidine alkaloid 167B

  摘要：

  The synthetic access to indolizidines, substituted in C-5 position, was reported with good diastereoselectivity. The strategy developed was based on a key step of Michael addition associated with a Clauson-Kaas condensation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.105

文献信息

• Straightforward synthesis of indolizidine alkaloid 167B
  作者：Stéphanie Gracia、Rudolf Jerpan、Stéphane Pellet-Rostaing、Florence Popowycz、Marc Lemaire

  DOI：10.1016/j.tetlet.2010.09.105

  日期：2010.12

  The synthetic access to indolizidines, substituted in C-5 position, was reported with good diastereoselectivity. The strategy developed was based on a key step of Michael addition associated with a Clauson-Kaas condensation. (C) 2010 Elsevier Ltd. All rights reserved.