作者:Peter A. Jacobi、Prudencio Herradura
DOI:10.1016/s0040-4039(97)01533-5
日期:1997.9
(−)-Blastmycinolactol (1b) has been prepared in an enantioselective fashion from acetylenic acid 5 by a three step sequence involving debenzylation-lactonization, hydration with concurrent C3-epimerization, and Baeyer-Villiger oxidation accompanied by ester cleavage. Acylation of 1b with isovaleryl chloride then afforded (+)-blastmycinone (1a) in excellent overall yield. © 1997 Elsevier Science Ltd
(-)-Blastmycinactactolactol(1b)已通过乙炔酸5的对映选择性方式通过三步序列制备,该过程涉及脱苄基化-内酯化,水合并同时进行C 3-表异构化和Baeyer-Villiger氧化并伴随酯裂解。然后用异戊酰氯酰化1b,从而以优异的总收率得到(+)-blastmycinone(1a)。©1997爱思唯尔科学有限公司。