ethyl 3-ethoxy-2-propenoate | 40648-44-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 3-ethoxy-2-propenoate
• 英文别名: ethyl 3-ethoxyacrylate；cis-3-Ethoxy-acrylsaeure-ethylester；β-ethoxyacrylic acid ethyl ester；(Z)-ethyl 3-ethoxyacrylate；cis-3-ethoxy-acrylic acid ethyl ester；B-ethoxyacrylic acid ethyl ester；ethyl (Z)-3-ethoxyprop-2-enoate
• CAS: 40648-44-0
• 化学式: C₇H₁₂O₃
• 分子量: 144.17
• InChiKey: ITQFPVUDTFABDH-WAYWQWQTSA-N

物化性质

• 沸点：
  60-61 °C(Press: 0.5 Torr)
• 密度：
  0.977±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 3-ethoxy-2-propenoate 在 lithium hexamethyldisilazane 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 反应 1.5h， 生成 1-环丙基-6,7-二氟-4-氧代-1,4-二氢喹啉-3-羧酸乙酯
  参考文献：
  名称：

  [EN] STREAMLINED SYNTHESES OF FLUOROQUINOLONES
  [FR] SYNTHÈSES RATIONALISÉES DE FLUOROQUINOLONES

  摘要：

  公开号：

  WO2018231747A3
• 作为产物：
  描述：

  3,3-二乙氧基丙酸乙酯 在 2,6-二叔丁基-4-甲基苯酚 、 三乙胺盐酸盐 作用下， 以93%的产率得到ethyl 3-ethoxy-2-propenoate
  参考文献：
  名称：

  Anticoccidial activity of 1-phenyluracils

  摘要：

  The minimum effective concentration (MEC) of 6-azauracil against Eimeria tenella when incorporated in feed is about 1000 ppm. Attachment of suitably substituted phenyl side chains at the 1-position reduces the MEC to less than 1 ppm. Uracil itself is devoid of anticoccidial activity, but side chains attached at the 1-position potentiate uracil and result in activity against E. tenella. Although effective at levels as low as 60 ppm, the 1-phenyluracils are less active than the corresponding 1-phenyl-6-azauracils. They also are less acidic.

  DOI：

  10.1021/jm00361a024

文献信息

• Claisen orthoester rearrangement in the direct preparation of Z-isositsirikine and Z-geissoschizine derivatives possessing the right oxidation state at C-17
  作者：Mauri Lounasmaa、Pirjo Hanhinen、Reija Jokela

  DOI：10.1016/0040-4020(95)00477-p

  日期：1995.7

  In the cases of trialkyl 3,3-dialkoxyorthopropionates [triethyl 3,3-diethoxyorthopropionate 14b (or 3,3-diethoxymethylketene diethylacetal 20b) and trimethyl 3,3-dimethoxyorthopropionate 14 a (or 3,3-dimethoxymethylketene dimethylacetal 20a)], the intermediate ketene acetals 25a,b do not rearrange according to the Claisen mechanism to form compounds 26a,b and/or 27a,b possessing two RO-functions at

  利用烯丙醇1（或2）和3-甲氧基ortbopropionate三甲基丙烯酸13a进行的Claisen原酸酯重排导致Z-异三烷衍生物21a-22a（或23a-24a）在C-17处具有一个RO功能。在三烷基3,3- dialkoxyorthopropionates的情况下[三乙基3,3- diethoxyorthopropionate 14B（或3,3-二乙diethoxymethylketene 20B）和三甲基3,3- dimethoxyorthopropionate 14（或3,3-二甲基缩醛dimethoxymethylketene 20A）]，则中间乙烯酮缩醛25a，b不会根据克莱森机理进行重排以形成化合物26a，b和/或27a，b在C-17上具有两个RO功能。描述了中间体原酸酯的合成，即3-甲氧基原丙酸三甲酯13a，3，3-二甲氧基原丙酸三甲酯14a，反式-3-甲氧基原丙酸三甲酯2
• [EN] NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS<br/>[FR] NOUVEAUX COMPOSES 2-ARYLTHIAZOLE UTILISES COMME AGONISTES DES RECEPTEURS PPARALPHA ET PPARGAMMA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004020420A1

  公开（公告）日：2004-03-11

  The present invention relates to compounds of formula (I) wherein Rl to R10, X, Y and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.

  本发明涉及式(I)的化合物，其中R1至R10、X、Y和n如描述和权利要求中所定义，并且其药学上可接受的盐和酯。这些化合物对于治疗疾病如糖尿病是有用的。
• Catalytic Synthesis of 3-Alkoxyacrylic Acid Esters Under Neat Conditions
  作者：Junhua Wang、Honglin Wang、Hongmin Ren

  DOI：10.1080/00397910903029875

  日期：2010.3.12

  Triethylamine or Ph3P (0.05 eq.) was found to catalyze the addition of alcohols to alkyl propiolates. The reaction occurred much more rapidly without solvent than in solvent. The E/Z ratio was relative to the reaction temperature. Water was found to inhibit the reaction.

  发现三乙胺或 Ph3P（0.05 当量）可催化醇加成到丙炔酸烷基酯。反应在没有溶剂的情况下比在溶剂中发生得快得多。E/Z 比与反应温度有关。发现水抑制反应。
• 置換ビニルエーテル誘導体の製造方法
  申请人：三菱化学株式会社

  公开号：JP2005170912A

  公开（公告）日：2005-06-30

  PROBLEM TO BE SOLVED: To provide a method for producing a substituted vinyl ether derivative by ether exchange from a substituted vinyl ether which has an electron-attracting group as a substituent on a double bond carbon atom to cause the binding site to be electron-deficient.

  SOLUTION: The method for producing a substituted vinyl ether derivative comprises subjecting a substituted vinyl ether, which has at least one electron-attracting group as a substituent on a carbon atom which forms carbon-carbon double bond, to ether exchange reaction with an alcohol or a phenol in the presence of a catalyst containing a compound of the group 9 and/or 10 metal in the periodic table, wherein the compound has a counter anion, and when the anion is protonated, the proton has an ionization constant (pKa) of 0 or less.

  COPYRIGHT: (C)2005,JPO&NCIPI

  待解决问题：提供一种通过醚交换从具有电子吸引基团作为双键碳原子上取代基的取代乙烯醚中产生取代乙烯醚衍生物的方法，以使结合位点成为电子不足的情况。 解决方案：制备取代乙烯醚衍生物的方法包括将至少具有一个电子吸引基团作为形成碳-碳双键的碳原子的取代乙烯醚与醇或酚在含有周期表中9和/或10金属群化合物的催化剂存在下进行醚交换反应，其中该化合物具有反离子，当该离子质子化时，质子具有离解常数（pKa）为0或更低。 版权所有：（C）2005，JPO＆NCIPI
• PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES
  申请人：Wrobleski Stephen T.

  公开号：US20140011800A1

  公开（公告）日：2014-01-09

  The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

  本发明提供了I型化合物及其药学上可接受的盐。式I化合物抑制JAK3的酪氨酸激酶活性，因此可用于治疗炎症和自身免疫性疾病。