2-羟基亚氨基对甲苯乙酰胺 | 1132-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基亚氨基对甲苯乙酰胺
• 中文别名: 2-羟基亚胺-N-(4-甲基苯基)-乙酰胺
• 英文名称: 2-(hydroxyimino)-N-(4-methylphenyl)acetamide
• 英文别名: 2-Hydroxyimino-N-p-tolyl-acetamide；(2E)-2-hydroxyimino-N-(4-methylphenyl)acetamide
• CAS: 1132-40-7
• 化学式: C₉H₁₀N₂O₂
• mdl: MFCD00178295
• 分子量: 178.191
• InChiKey: AEWRKRLVPROQRN-UXBLZVDNSA-N

物化性质

• 熔点：
  155-156 °C
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  2-羟基亚氨基对甲苯乙酰胺 生成 5-甲基靛红
  参考文献：
  名称：

  STANKYAVICHYUS, A. P.;MAZHILIS, L. I.;GARALENE, V. N.;RISYALIS, S. P.;SAP+, XIM.-FARMATS. ZH., 1981, 15, N 12, 31-34

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-N-(4-甲基苯基)乙酰胺 在 盐酸羟胺 、 二甲基亚砜 、 sodium hydroxide 作用下， 反应 24.0h， 以54%的产率得到2-羟基亚氨基对甲苯乙酰胺
  参考文献：
  名称：

  2-羟基烷酰胺肟的新合成

  摘要：

  在碱的存在下，α-卤代羧酸酰胺与3当量的盐酸羟胺的反应涉及形成卤原子的亲核取代产物，然后将其氧化成相应的肟。一锅转化可在各种非质子溶剂或80°C的乙醇中完成。二甲基亚砜作为溶剂可确保对氧化产物的最高选择性。N-取代的2-（羟基亚氨基）羧酸酰胺的产率为22-92％。

  DOI：

  10.1134/s1070428019040201

文献信息

• DIHYDROOROTATE DEHYDROGENASE INHIBITORS
  申请人：Thunuguntla Siva Sanjeeva Rao

  公开号：US20120028959A1

  公开（公告）日：2012-02-02

  The invention relates to compounds of formula (I) wherein R 1 , R 2 , X 1 , X 2 , Y, R a , R b , Q have the meanings given in claim 1 . The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.

  本发明涉及式(I)的化合物，其中R1、R2、X1、X2、Y、Ra、Rb、Q的含义如权利要求书所述。该化合物在治疗自身免疫性疾病，如多发性硬化症，以及治疗癌症方面具有有用性。
• Change of the Load State of Mhc Molecules
  申请人：Falk Kirsten

  公开号：US20070280957A1

  公开（公告）日：2007-12-06

  The present invention relates to methods for changing the load state of MHC molecules with ligands, the change in the load state being catalysed by a compound of formulae I, IA, II, III or IV1 to IV3. The invention relates further to the use of compounds of formulae I, IA, II, III or IV1 to IV3 or to the use of MHC molecules loaded with ligands, which molecules can be prepared by a method according to the invention, for the treatment of disorders or conditions that are associated with various pathologically excessive or absent immune responses and also for triggering tumour-specific, pathogen-specific or autoreactive immune responses. The invention additionally relates to the use of such compounds for the treatment and diagnosis of cancer, infectious diseases, autoimmune diseases and for attenuating aggressive immune reactions, as well as to the preparation of a vaccine or of a pharmaceutical composition for the treatment of the mentioned disorders or conditions.
• US9006454B2
  申请人：——

  公开号：US9006454B2

  公开（公告）日：2015-04-14
• [EN] DIHYDROOROTATE DEHYDROGENASE INHIBITORS<br/>[FR] INHIBITEURS DE LA DIHYDROOROTATE DÉSHYDROGÉNASE
  申请人：MERCK SERONO SA

  公开号：WO2010115736A2

  公开（公告）日：2010-10-14

  The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.
• New Synthesis of 2-Oxoalkanamide Oximes
  作者：S. N. Mantrov、Yu. M. Lapina、E. A. Shukhtina

  DOI：10.1134/s1070428019040201

  日期：2019.4

  Reactions of α-halocarboxylic acid amides with 3 equiv of hydroxylamine hydrochloride in the presence of bases involves formation of products of nucleophilic substitution of the halogen atom and their subsequent oxidation to the corresponding oximes. This one-pot transformation can be accomplished in various aprotic solvents or ethanol at 80°C. Dimethyl sulfoxide as solvent ensures the highest selectivity

  在碱的存在下，α-卤代羧酸酰胺与3当量的盐酸羟胺的反应涉及形成卤原子的亲核取代产物，然后将其氧化成相应的肟。一锅转化可在各种非质子溶剂或80°C的乙醇中完成。二甲基亚砜作为溶剂可确保对氧化产物的最高选择性。N-取代的2-（羟基亚氨基）羧酸酰胺的产率为22-92％。