methyl 7-nitro-2,3,4,5-tetrahydro-1H-3-benzazepine-3-carboxylate | 444588-23-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: methyl 7-nitro-2,3,4,5-tetrahydro-1H-3-benzazepine-3-carboxylate
• 英文别名: methyl 7-nitro-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylate
• CAS: 444588-23-2
• 化学式: C₁₂H₁₄N₂O₄
• 分子量: 250.254
• InChiKey: TXPFXLXNMOYIDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  75.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 7-nitro-2,3,4,5-tetrahydro-1H-3-benzazepine-3-carboxylate 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 7-氨基-1,2,4,5-四氢-3H-3-苯并氮杂卓-3-羧酸甲酯
  参考文献：
  名称：

  Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials

  摘要：

  Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.07.017
• 作为产物：
  描述：

  2,3,4,5 -四氢-1H -苯并[D]氮杂卓 在 硝酸铵 、 硫酸 、 碳酸氢钠 作用下， 以 四氢呋喃 为溶剂， 生成 methyl 7-nitro-2,3,4,5-tetrahydro-1H-3-benzazepine-3-carboxylate
  参考文献：
  名称：

  Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials

  摘要：

  Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.07.017

文献信息

• Oxazolidinones having a benzannulated 6- or 7-membered heterocycle
  申请人：——

  公开号：US20020133021A1

  公开（公告）日：2002-09-19

  The present invention provides oxazolidinones having a benzannelated 6- or 7-membered heterocycle as antibacterial agents.

  本发明提供了具有苯并环的6-或7-员杂环的噁唑烷酮类作为抗菌剂。
• Therapeutic compounds
  申请人：——

  公开号：US20030149024A1

  公开（公告）日：2003-08-07

  The present invention provides compounds of Formula I: 1 wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of Formula I.

  本发明提供了公式I的化合物：1其中X，R1，R2，R3，R4，R5和R6具有规范中定义的任何值，以及包含该化合物的制药组合物。该发明还提供了治疗方法以及用于制备公式I化合物的过程和中间体。
• Indoles and indolines having 5-HT activity
  申请人：——

  公开号：US20030060458A1

  公开（公告）日：2003-03-27

  The present invention provides compounds of Formula (I): 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and — have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of Formula (I). The compounds are useful as 5-HT ligands.

  本发明提供了公式（I）的化合物：1其中R1、R2、R3、R4、R5、R6和-具有规范中定义的任何值，以及包含该化合物的制药组合物。本发明还提供了治疗方法以及用于制备公式（I）化合物的过程和中间体。该化合物可用作5-HT配体。
• Oxazolidinones having a benzannulated 6- or 7-membered heterocycle
  申请人：Johnson Paul D.

  公开号：US06972286B2

  公开（公告）日：2005-12-06

  The present invention provides oxazolidinones having a benzannelated 6- or 7-membered heterocycle as antibacterial agents.

  本发明提供了带有苯并6-或7-成员杂环的噁唑烷类化合物作为抗菌剂。
• DRUGS FOR DIABETES
  申请人：Nicox S.A.

  公开号：EP1324974A2

  公开（公告）日：2003-07-09