3-Deoxy-3-fluor-α,(β)-D-glucose | 7226-70-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Deoxy-3-fluor-α,(β)-D-glucose
• 英文别名: 3-Deoxy-3-fluoro-D-[1-13C]glucose；4-fluoro-6-(hydroxymethyl)oxane-2,3,5-triol
• CAS: 7226-70-2；22435-77-4；31001-26-0；31001-27-1；86258-31-3；86334-54-5
• 化学式: C₆H₁₁FO₅
• mdl: MFCD04037832
• 分子量: 182.149
• InChiKey: BUMRBAMACDBPKO-UHFFFAOYSA-N

物化性质

• 沸点：
  408.6±45.0 °C(Predicted)
• 密度：
  1.59±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• NOVEL AROMATIC FLUOROGLYCOSIDE DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF
  申请人：FRICK Wendelin

  公开号：US20080108580A1

  公开（公告）日：2008-05-08

  Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and process for their preparation. The compounds are suitable for example as antidiabetics.

  小说芳香族氟代糖苷衍生物，含有这些化合物的药物，以及它们的使用。本发明涉及式I的取代芳香族氟代糖苷衍生物，其中基团具有所述的含义，以及其生理上耐受的盐和制备过程。这些化合物例如适用于抗糖尿病药物。
• USE OF COMPOUNDS WITH SGLT-1/SGLT-2 INHIBITOR ACTIVITY FOR PRODUCING MEDICAMENTS FOR TREATMENT OF BONE DISEASE
  申请人：Kissner Thomas

  公开号：US20120270819A1

  公开（公告）日：2012-10-25

  Use of compounds with SGLT-1/SGLT-2 inhibitor activity for producing medicaments for treatment of bone diseases The invention relates to the use of compounds with SGLT-1/SGLT-2 inhibitor activity for producing medicaments for treatment of bone diseases like osteoporosis. Preferred is the use of compounds of the formula I in which the radicals have the stated meanings.

  使用具有SGLT-1/SGLT-2抑制剂活性的化合物制备用于治疗骨疾病的药物。本发明涉及使用具有SGLT-1/SGLT-2抑制剂活性的化合物制备用于治疗骨疾病，如骨质疏松症的药物。首选使用式I中基团具有所述含义的化合物。
• Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
  申请人：FRICK Wendelin

  公开号：US20100261664A1

  公开（公告）日：2010-10-14

  Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof The invention relates to substituted heterocyclic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation. The compounds are suitable for example as antidiabetics.

  新型杂环氟代糖苷衍生物、含有这些化合物的药物以及它们的使用本发明涉及公式I的取代的杂环氟代糖苷衍生物，其中基团具有所述的含义，以及它们的生理上耐受的盐和制备它们的过程。这些化合物例如适用于抗糖尿病。
• MONOSACCHARIDE-BASED COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE AND INFLAMMATORY DERMATOLOGICAL DISEASES
  申请人：Priebe Waldemar

  公开号：US20120276108A1

  公开（公告）日：2012-11-01

  The present invention relates to compounds and methods which may be useful as inhibitors of glycolysis, inhibitors of protein glycosylation, anti-virals, and down-regulators of insulin receptor and IGF-1 receptor for the treatment or prevention of inflammatory dermatological diseases or proliferative dermatological diseases.
• US7160865B2
  申请人：——

  公开号：US7160865B2

  公开（公告）日：2007-01-09