2-(2',3'-epoxypropoxy)-acetophenone | 147849-90-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2',3'-epoxypropoxy)-acetophenone
• 英文别名: 2-(Oxiran-2-ylmethoxy)-1-phenylethanone
• CAS: 147849-90-9
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: LAHMJGVERPBCOS-UHFFFAOYSA-N

物化性质

• 沸点：
  328.4±22.0 °C(Predicted)
• 密度：
  1.171±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2',3'-epoxypropoxy)-acetophenone 、 1-(4-氯苯基)哌嗪 以 丙醇 、 乙醇 为溶剂， 生成 1-[2-Carbonylmethyl-phenoxy]-3-[4-(4-chlorophenyl)-piperazin-1-yl]-propan-2-ol.HCl
  参考文献：
  名称：

  (Hetarylphenoxy)-(phenylpiperazinyl)-propanols, their preparation and

  摘要：

  新颖的(杂芳基氧基)-(苯基哌嗪基)-丙醇化合物的化学式为##STR1##其中R.sup.1为氢、氨基或1至4个碳原子的烷基，R.sup.2为氢、卤素、1至4个碳原子的烷基或烷氧基，其中烷基为1至3个碳原子，苯环可以被R.sup.2单取代或双取代，杂环结构Het.为嘧啶基、三唑-1-基、咪唑-1-基、吡唑-3-基或异噁唑-3-基，以及它们与酸形成的生理上耐受的加盐物，它们的制备方法，以及含有这些化合物并主要具有降压、镇静、神经阻滞和支气管扩张作用的药物配方。

  公开号：

  US04428950A1
• 作为产物：
  描述：

  环氧氯丙烷 、 2-羟基苯乙酮 生成 2-(2',3'-epoxypropoxy)-acetophenone
  参考文献：
  名称：

  LIETZ, H.

  摘要：

  DOI：

文献信息

• Organic thiol metal-free stabilizers and plasticizers for halogen-containing polymers
  申请人：Starnes Herbert William

  公开号：US20050049307A1

  公开（公告）日：2005-03-03

  Organic thiol compounds based on pentaerythritol and dipentaerythritol are described herein. More specifically, the compounds of the present invention are mixed esters of pentaerythritol and dipentaerythritol having at least one sulfhydryl group and preferably a plurality of sulfhydryl groups as well as at least one non-thiol-containing group. The organic thiol compounds are utilized to plasticize and/or heat stabilize halogen-containing polymer compositions especially poly(vinyl chloride) compositions. The compositions are substantially free or free of metal-based stabilizers, Lewis acids and terpenes. The compounds of the present invention are ideally utilized in polymers normally susceptible to deterioration and color change which can occur during processing of the polymer or exposure of the polymer to certain environments and surprisingly also serve as excellent plasticizers.

  本文描述了基于对羟基甲苯和二对羟基甲苯的有机硫醇化合物。更具体地说，本发明的化合物是对羟基甲苯和二对羟基甲苯的混合酯，具有至少一个巯基和最好是多个巯基，以及至少一个非巯基含有基团。这些有机硫醇化合物被用于增塑和/或热稳定含卤素聚合物组合物，特别是聚氯乙烯组合物。这些组合物基本上不含或不含金属基稳定剂、路易斯酸和萜类物质。本发明的化合物在通常容易恶化和变色的聚合物中得到理想应用，这种恶化和变色可能发生在聚合物加工过程中或聚合物暴露于某些环境中，并且令人惊讶地还可作为优秀的增塑剂。
• Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and
  申请人：BASF Aktiengesellschaft

  公开号：US05118685A1

  公开（公告）日：1992-06-02

  Aminopropanol derivatives of the formula: ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R.sup.1 and R.sup.2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and -- .circle.Het is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4-yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, and antiarrhythmic agents containing these compounds.

  化合物的氨基丙醇衍生物的化学式：##STR1## 其中R.sup.1和R.sup.2相同或不同，分别为氢，烷基，环烷基，烯基，炔基或羟基烷基，每个不超过6个碳原子，烷氧基烷基，烷硫基烷基或二烷基氨基烷基，每个总共不超过9个碳原子，或苯基烷基或苯氧基烷基，其中烷基基团不超过6个碳原子，苯基基团未取代或被烷基或烷氧基取代，每个不超过3个碳原子，或R.sup.1和R.sup.2与连接它们的氮原子一起形成一个5-成员至7-成员饱和杂环环，可以被一个或两个苯基和/或羟基基团取代，并且可以包含一个氧或氮原子作为环中的进一步杂原子，并且这样的额外氮原子可以被1至3个碳原子的烷基或苯基取代，-- .circle.Het是噻吩-2-基，噻吩-3-基，吡啶-2-基，吡啶-3-基，吡啶-4-基，呋喃-2-基，1-烷基吡咯-2-基，1-烷基吡咯-3-基或1-烷基吡唑-4-基，其中烷基为1至3个碳原子，以及它们与酸的生理耐受性加合物和含有这些化合物的抗心律失常药物。
• Latent mercaptans as multi-functional additives for halogen-containing polymer compositions
  申请人：——

  公开号：US20030216493A1

  公开（公告）日：2003-11-20

  Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan. The latent mercaptans also serve as intermediates in the preparation of anti-oxidants, anti-microbial agents, photostabilizers, and primary heat stabilizers. Highly effective heat stabilizers are prepared by the condensation of formaldehyde and a para-phenol and further condensation of the crude product with a mercapto-containing compound.

  含卤素聚合物组合物包括一种潜在的巯基含量热稳定剂组合物，该组合物基本上不含有通常与巯基相关联的刺激性气味，在加工过程中通过潜在（即被阻断的）巯基的降解产物（包括自由巯基）来保护。降解的其他产物被认为包括阻断基的碳正离子，其通过电子亏损由几个基团共享的分子结构稳定。潜在巯基可以是唯一的热稳定剂添加剂，但在加工过程中释放的自由巯基也可以协同作用于金属基热稳定剂，如金属盐和有机金属稳定剂，如有机锡羧酸盐和巯基化合物在聚合物组合物中的活性。通过少量潜在巯基掩盖含有主要巯基热稳定剂的卤化聚合物组合物的气味。潜在巯基还可用作抗氧化剂、抗微生物剂、光稳定剂和主要热稳定剂的制备中间体。通过甲醛和对苯酚的缩合，并将粗产品与含巯基的化合物进一步缩合，可以制备高效的热稳定剂。
• LATENT MERCAPTANS AS MULTI-FUNCTIONAL ADDITIVES FOR HALOGEN-CONTAINING POLYMER COMPOSITIONS
  申请人：——

  公开号：US20020068780A1

  公开（公告）日：2002-06-06

  Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan. The latent mercaptans also serve as intermediates in the preparation of anti-oxidants, anti-microbial agents, photostabilizers, and primary heat stabilizers. Highly effective heat stabilizers are prepared by the condensation of formaldehyde and a para-phenol and further condensation of the crude product with a mercapto-containing compound.

  含卤素的聚合物组合物包括一种潜在的巯基含量热稳定剂组合物，该组合物基本上不含通常与巯基相关的刺激性气味，通过潜在（即阻塞）巯基的降解产物，包括自由巯基，来保护加工过程中的聚合物组合物。降解的其他产物被认为包括阻塞基的碳正离子，其由多个基团共享电子亏损的分子结构稳定。潜在巯基可以是唯一的热稳定剂添加剂，但在加工过程中释放的自由巯基也可以协同金属基热稳定剂（如金属盐）和有机金属稳定剂（如有机锡羧酸盐和巯基化合物）的活性。在卤化聚合物组合物中，主要巯基含量热稳定剂的气味被少量潜在巯基掩盖。潜在巯基还可用作抗氧化剂、抗微生物剂、光稳定剂和主要热稳定剂的制备中间体。通过甲醛和对苯酚的缩聚，并将粗品与含巯基化合物进一步缩聚，制备出高效的热稳定剂。
• Phenylpiperazinyl-propanole von Hetarylphenolen, ihre Herstellung und diese enthaltende therapeutische Mittel
  申请人：BASF Aktiengesellschaft

  公开号：EP0056486A2

  公开（公告）日：1982-07-28

  Die Erfindung betrifft neue Phenylpiperazinylpropanole von Hetarylphenolen der Formel in denen R1 ein Wasserstoffatom, eine Aminogruppe oder einen Alkylrest mit 1 bis 4 C-Atomen, R2 ein Wasserstoffatom, ein Halogenatom, einen Alkylrest mit 1 bis 4 C-Atomen oder einen Alkoxyrest mit 1 bis 3 C-Atomen im Alkyl, wobei R2 als Substituent des Phenylringes ein- oder zweifach vorhanden sein kann, bedeuten und als Heterocyclus Het. ein Pyrimidinrest, ein Triazol-1-yl- ein Imidazol-1-yl, ein Pyrazol-3-yl oder ein Isoxazol-3-yl-rest steht, und ihre physiologisch verträglichen Säureadditionssalze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen, die vorwiegend blutdrucksenkende, sedative, neuroleptische sowie broncholytische Eigenschaften aufweisen.

  本发明涉及新的苯基哌嗪基丙醇，其式为 其中 R1 是氢原子、氨基或具有 1 至 4 个碳原子的烷基，R2 是氢原子、卤素原子、具有 1 至 4 个碳原子的烷基或烷基中具有 1 至 3 个碳原子的烷氧基，R2 可以作为苯环的取代基存在一次或两次，杂环 Het.是嘧啶基、三唑-1-基、咪唑-1-基、吡唑-3-基或异噁唑-3-基，以及它们在生理上可耐受的酸加成盐、其制备工艺和含有这些化合物的药物组合物，这些化合物主要具有降压、镇静、神经安定和支气管舒张等特性。