O-isopentylhydroxylamine | 19411-65-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-isopentylhydroxylamine
• 英文别名: O-iso-Amylhydroxylamin；O-(3-methylbutyl)hydroxylamine
• CAS: 19411-65-5
• 化学式: C₅H₁₃NO
• 分子量: 103.164
• InChiKey: PXWPXXJVCQOIPH-UHFFFAOYSA-N

物化性质

• 沸点：
  130-132 °C
• 密度：
  0.849±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  O-isopentylhydroxylamine 、 S-甲基异硫脲硫酸盐 在 乙醇 作用下， 生成 isopentyloxy-guanidine
  参考文献：
  名称：

  The Synthesis of Certain O-Substituted Derivatives of Hydroxyguanidine and Hydroxybiguanide¹

  摘要：

  DOI：

  10.1021/ja01585a022
• 作为产物：
  描述：

  异戊基碘 在 氢氧化钾 作用下， 生成 O-isopentylhydroxylamine
  参考文献：
  名称：

  The Synthesis of Certain O-Substituted Derivatives of Hydroxyguanidine and Hydroxybiguanide¹

  摘要：

  DOI：

  10.1021/ja01585a022

文献信息

• 벤조페논 유도체, 이의 제조방법 및 이를 포함하는 B형간염 치료용 약학적 조성물
  申请人：University-Industry Cooperation Group of Kyung Hee University 경희대학교 산학협력단(220040073623) BRN ▼135-82-10789

  公开号：KR20190023760A

  公开（公告）日：2019-03-08

  본 발명은 벤조페논 유도체, 이의 제조방법 및 이를 포함하는 B형간염 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 화학식 1로 표시되는 화합물은 HBsAg분비 및 HBeAg 분비를 감소시키며, HBV바이러스 수준이 감소하는 효과가 있고, pgRNA생성 억제 및 cccDNA 생성을 억제하는 효과가 우수하므로, HBV 질환의 예방 또는 치료용 약학적 조성물로 유용할 수 있다.

  这项发明涉及苯甲酮衍生物，其制备方法以及用于治疗乙型肝炎的药物组合物。根据本发明，用化学式1表示的化合物具有减少HBsAg和HBeAg分泌以及降低HBV病毒水平的作用，同时具有抑制pgRNA生成和cccDNA生成的优秀效果，因此可用作预防或治疗乙型肝炎的药物组合物。
• An Effective Antiviral Approach Targeting Hepatitis B Virus with NJK14047, a Novel and Selective Biphenyl Amide p38 Mitogen-Activated Protein Kinase Inhibitor
  作者：So-Young Kim、Hong Kim、Sang-Won Kim、Na-Rae Lee、Chae-Min Yi、Jinyuk Heo、Bum-Joon Kim、Nam-Jung Kim、Kyung-Soo Inn

  DOI：10.1128/aac.00214-17

  日期：2017.8

  Despite recent advances in therapeutic strategies against hepatitis B virus (HBV) infection, chronic hepatitis B remains a major global health burden. Recent studies have shown that targeting host factors instead of viral factors can be an effective antiviral strategy with low risk of the development of resistance. Efforts to identify host factors affecting viral replication have identified p38 mitogen-activated protein kinase (MAPK) as a possible target for antiviral strategies against various viruses, including HBV. Here, a series of biphenyl amides were synthesized as novel p38 MAPK selective inhibitors and assessed for their anti-HBV activities. The suppression of HBV surface antigen (HBsAg) production by these compounds was positively correlated with p38 MAPK-inhibitory activity. The selected compound NJK14047 displayed significant anti-HBV activity, as determined by HBsAg production, HBeAg secretion, and HBV production. NJK14047 efficiently suppressed the secretion of HBV antigens and HBV particles from HBV genome-transfected cells and HBV-infected sodium taurocholate cotransporting polypeptide-expressing human hepatoma cells. Furthermore, NJK14047 treatment resulted in a significant decrease of pregenomic RNA and covalently closed circular DNA (cccDNA) of HBV in HBV-harboring cells, indicating its ability to inhibit HBV replication. Considering that suppression of HBsAg secretion and elimination of cccDNA of HBV are the major aims of anti-HBV therapeutic strategies, the results suggested the potential use of these compounds as a novel class of anti-HBV agents targeting host factors critical for viral infection.

  摘要 尽管针对乙型肝炎病毒（HBV）感染的治疗策略取得了最新进展，但慢性乙型肝炎仍是全球主要的健康负担。最近的研究表明，针对宿主因素而非病毒因素是一种有效的抗病毒策略，而且产生耐药性的风险较低。为确定影响病毒复制的宿主因素所做的努力发现，p38 丝裂原活化蛋白激酶（MAPK）可能是包括 HBV 在内的各种病毒抗病毒策略的靶点。在此，我们合成了一系列联苯酰胺作为新型 p38 MAPK 选择性抑制剂，并评估了它们的抗 HBV 活性。这些化合物对 HBV 表面抗原（HBsAg）产生的抑制作用与 p38 MAPK 抑制活性呈正相关。根据 HBsAg 生成量、HBeAg 分泌量和 HBV 生成量的测定，所选化合物 NJK14047 显示出显著的抗 HBV 活性。NJK14047 能有效抑制 HBV 基因组转染细胞和 HBV 感染的表达牛磺胆酸钠共转运多肽的人肝癌细胞分泌 HBV 抗原和 HBV 颗粒。此外，NJK14047 还能显著减少 HBV 携带细胞中 HBV 的前基因组 RNA 和共价闭合环状 DNA（cccDNA），这表明它具有抑制 HBV 复制的能力。考虑到抑制 HBsAg 的分泌和消除 HBV 的 cccDNA 是抗 HBV 治疗策略的主要目标，研究结果表明，这些化合物有可能被用作一类新型的抗 HBV 药物，针对病毒感染的关键宿主因子。
• 3-Alkoxy-1,5-bis(aryl)imidazolidine-2,4-diones, synthesis and structure
  作者：Vasiliy G. Shtamburg、Victor V. Shtamburg、Andrey A. Anishchenko、Alexander V. Mazepa、Eduard B. Rusanov

  DOI：10.1016/j.molstruc.2022.133259

  日期：2022.9
• The Synthesis of Certain O-Substituted Derivatives of Hydroxyguanidine and Hydroxybiguanide¹
  作者：David D. Nyberg、Bert E. Christensen

  DOI：10.1021/ja01585a022

  日期：1956.2