6''-O-p-Coumaroyltrifolin | 68170-52-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6''-O-p-Coumaroyltrifolin
• 英文别名: [6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl (E)-3-(4-hydroxyphenyl)prop-2-enoate
• CAS: 68170-52-5
• 化学式: C₃₀H₂₆O₁₃
• 分子量: 594.5
• InChiKey: DVGGLGXQSFURLP-XCVCLJGOSA-N

物化性质

• 沸点：
  943.9±65.0 °C(Predicted)
• 密度：
  1.68±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  213
• 氢给体数：
  7
• 氢受体数：
  13

文献信息

• FLAVONE DERIVATIVES AND THEIR PREPARATIVE METHOD AND MEDICAL USE
  申请人：Duan Hongquan

  公开号：US20130231492A1

  公开（公告）日：2013-09-05

  Flavone derivatives, preparative method of the derivatives and use thereof as medicaments for treating diabetes. The structure of the derivatives is presented by formula 1: In the structure, R 1 and R 2 , which are identical or not, represent hydrogen atom, halogen, cyano, hydroxyl, trifluoromethyl, thio-methyl, benzyloxy, C1-C8 linear chain or branch chain alkyl, C1-C8 linear chain or branch chain alkoxy. The pharmacological test indicates that the flavone derivatives can significantly increase the glucose consumption of Hep-G2 cell with insulin resistance activity, promote translocation of glucose transporter 4 of skeletal muscle cells (L6GLUT4myc) at different level, and significantly increase glucose intake and utilization by cells. The test proves the fact for the first time that the flavone derivatives can significantly promote translocation of glucose transporter 4 of skeletal muscle cells, and one of the mechanisms for treating diabetes is activating the cell AMPK phosphorylation and phosphorylating the downstream ACC.

  黄酮衍生物、其衍生物的制备方法及其用作治疗糖尿病的药物。衍生物的结构由公式1表示：在结构中，R1和R2相同或不相同，代表氢原子、卤素、氰基、羟基、三氟甲基、硫甲基、苄氧基、C1-C8直链或支链烷基、C1-C8直链或支链烷氧基。药理测试表明，黄酮衍生物能显著增加具有胰岛素抵抗活性的Hep-G2细胞的葡萄糖消耗量，以不同水平促进骨骼肌细胞（L6GLUT4myc）的葡萄糖转运蛋白4的转位，并显著增加细胞对葡萄糖的摄取和利用。该测试首次证实了黄酮衍生物能显著促进骨骼肌细胞的葡萄糖转运蛋白4的转位，并且治疗糖尿病的机制之一是通过激活细胞AMPK磷酸化和磷酸化下游的ACC。
• Flavonoid complexes with cyclodextrins
  申请人：Wirth Corinna

  公开号：US20070155695A1

  公开（公告）日：2007-07-05

  The invention relates to complexes of certain flavonoid derivatives, of the formula I compositions which comprise such derivatives, corresponding processes for the preparation of the flavonoid derivatives or of compositions comprising same, and the use thereof, in particular for the care, preservation or improvement of the general state of the skin or hair. Formula (1), in which Z 1 to Z 4 and Z 6 to Z 10 each, independently of one another, denote H, OH, CH 3 COO, alkoxy, hydroxyalkoxy, mono- or oligoglycoside radicals and where the alkoxy and hydroxyalkoxy groups may be branched and unbranched and can have 1 to 18 C atoms. Formula (II) denotes, Z 5 is a mono- or the oligoglycoside radical, where bonded to this glycoside radical, in each case via an —O— group, is at least one radical selected from certain benzo molecule.

  本发明涉及某些黄酮衍生物的复合物，具有I式的组成物，包括这些衍生物的制备方法或包含它们的组合物的制备方法，以及它们的用途，特别是用于皮肤或头发的护理、保护或改善。式（1）中，Z1至Z4和Z6至Z10各自独立地表示H、OH、CH3COO、烷氧基、羟基烷氧基、单糖或寡糖基团，其中烷氧基和羟基烷氧基基团可以是支链和直链的，并且可以具有1到18个C原子。式（II）表示，Z5是单糖或寡糖基团，其中通过每个—O—基团，与该糖基团结合的至少有一种来自某些苯并分子的基团。
• US7960430B2
  申请人：——

  公开号：US7960430B2

  公开（公告）日：2011-06-14
• US8946457B2
  申请人：——

  公开号：US8946457B2

  公开（公告）日：2015-02-03