5-[5-amino-1-(4′-chlorophenyl)-1H-pyrazole-4-yl]-1H-tetrazole | 1023551-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[5-amino-1-(4′-chlorophenyl)-1H-pyrazole-4-yl]-1H-tetrazole
• 英文别名: 2-(4-chlorophenyl)-4-(2H-tetrazol-5-yl)pyrazol-3-amine
• CAS: 1023551-84-9
• 化学式: C₁₀H₈ClN₇
• 分子量: 261.673
• InChiKey: DFTYVQITJHTYJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-氨基-1-(4-氯苯基)-4-氰基-1H-吡唑 在 sodium azide 、 氯化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以72%的产率得到5-[5-amino-1-(4′-chlorophenyl)-1H-pyrazole-4-yl]-1H-tetrazole
  参考文献：
  名称：

  Effectiveness of Novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole Derivatives Against Promastigotes and Amastigotes ofLeishmania amazonensis

  摘要：

  In this research, a series of substituted 5‐(5‐amino‐1‐aryl‐1H‐pyrazol‐4‐yl)‐1H‐tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania amazonensis. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI).

  DOI：

  10.1111/cbdd.12235

文献信息

• Effectiveness of Novel 5-(5-amino-1-aryl-1<i>H</i>-pyrazol-4-yl)-1<i>H</i>-tetrazole Derivatives Against Promastigotes and Amastigotes of<i>Leishmania amazonensis</i>
  作者：Viviane dos Santos Faiões、Leonor L. Leon、Marilene M. Canto-Cavalheiro、Eduardo C. Torres-Santos、Alice M. R. Bernardino、Percilene F. Vegi、Maurício S. dos Santos

  DOI：10.1111/cbdd.12235

  日期：2014.3

  In this research, a series of substituted 5‐(5‐amino‐1‐aryl‐1H‐pyrazol‐4‐yl)‐1H‐tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania amazonensis. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI).