1,3-dioxo-2,3-dihydro-1H-indene-5-carboxylic acid | 40462-10-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1,3-dioxo-2,3-dihydro-1H-indene-5-carboxylic acid
• 英文别名: 1,3-dioxoindene-5-carboxylic acid
• CAS: 40462-10-0
• 化学式: C₁₀H₆O₄
• 分子量: 190.155
• InChiKey: RBWIUPVTPMQHDU-UHFFFAOYSA-N

物化性质

• 沸点：
  476.9±45.0 °C(Predicted)
• 密度：
  1.532±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,5-二羟基苯甲醛 、 1,3-dioxo-2,3-dihydro-1H-indene-5-carboxylic acid 以 溶剂黄146 为溶剂， 反应 0.5h， 以32.5%的产率得到(Z)-2-(3,4-dihydroxybenzylidene)-1,3-dioxo-2,3-dihydro-1H-indene-5-carboxylic acid
  参考文献：
  名称：

  Discovery of new protein kinase CK2 inhibitors with 1,3-dioxo-2,3-dihydro-1H-indene core

  摘要：

  蛋白激酶CK2（CK2）作为一种具有吸引力的抗癌靶点。此处报道了具有1,3-二氧杂环-2,3-二氢-1H-茚核心的新型CK2抑制剂。

  DOI：

  10.1039/c6md00189k
• 作为产物：
  描述：

  乙酸酐 、 乙酰乙酸乙酯 、 偏苯三酸酐 在 三乙胺 、 三氟乙酸 作用下， 以 乙腈 为溶剂， 反应 14.0h， 以22.7%的产率得到1,3-dioxo-2,3-dihydro-1H-indene-5-carboxylic acid
  参考文献：
  名称：

  Discovery of new protein kinase CK2 inhibitors with 1,3-dioxo-2,3-dihydro-1H-indene core

  摘要：

  蛋白激酶CK2（CK2）作为一种具有吸引力的抗癌靶点。此处报道了具有1,3-二氧杂环-2,3-二氢-1H-茚核心的新型CK2抑制剂。

  DOI：

  10.1039/c6md00189k

文献信息

• Dye-Sensitized Photoelectric Conversion Device
  申请人：Shigaki Koichiro

  公开号：US20090044857A1

  公开（公告）日：2009-02-19

  Disclosed is a photoelectric conversion device wherein a methine dye represented by the formula (1) below is supported by a thin film of oxide semiconductor particles arranged on a substrate. Also disclosed is a solar cell manufactured by using such a photoelectric conversion device. (In the formula (1), n represents an integer of 0-5; m represents an integer of 0-5; R 1 -R 4 independently represent a hydrogen atom, an optionally substituted aromatic residue, an optionally substituted aliphatic hydrocarbon residue or the like; X and Y independently represent a hydrogen atom; an optionally substituted aromatic residue, an optionally substituted aliphatic hydrocarbon residue or the like; Z represents an oxygen atom, a sulfur atom or the like; A 1 , A 2 , A 3 , A 4 and A 5 independently represent a hydrogen atom, an optionally substituted aromatic residue, an optionally substituted aliphatic hydrocarbon residue or the like; and rings a, b and c may be substituted.)

  本发明公开了一种光电转换装置，其中通过在基板上排列的氧化物半导体颗粒薄膜上支持以下式(1)所表示的甲烷染料。同时，本发明还公开了使用这种光电转换装置制造的太阳能电池。(在式(1)中，n表示0-5的整数；m表示0-5的整数；R1-R4独立地表示氢原子、可选取代芳香基残基、可选取代脂肪烃基残基或类似物；X和Y独立地表示氢原子、可选取代芳香基残基、可选取代脂肪烃基残基或类似物；Z表示氧原子、硫原子或类似物；A1、A2、A3、A4和A5独立地表示氢原子、可选取代芳香基残基、可选取代脂肪烃基残基或类似物；环a、b和c可以被取代。)
• Dye-Sensitized Photoelectric Conversion Element
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：US20150076420A1

  公开（公告）日：2015-03-19

  A photoelectric conversion element which is obtained by having a thin film of fine oxide semiconductor particles support a methine-based dye that is represented by formula (1), said thin film being provided on a substrate. (In formula (1), m represents an integer of 1-5; each of l and n represents an integer of 0-6; each of j and k represents an integer of 0-3; each of X and Y represents a hydrogen atom, an aromatic residue, an aliphatic hydrocarbon residue or the like; each of Z 1 , Z 2 and Z 3 represents an oxygen atom, a sulfur atom or the like; each of A 1 , A 2 , A 3 , A 5 and A 6 represents a hydrogen atom, an aromatic residue, an aliphatic hydrocarbon residue or the like; A 4 represents a hydrogen atom, an aliphatic hydrocarbon residue or the like; each of A 7 , A 8 , A 9 and A 10 represents a hydrogen atom, an aliphatic hydrocarbon residue or the like; R 1 represents a group having a specific structure, an organic metal complex residue or the like; and R 2 represents a hydrogen atom, an aliphatic hydrocarbon residue, an organic metal complex residue or the like.)
• US8293847B2
  申请人：——

  公开号：US8293847B2

  公开（公告）日：2012-10-23
• US8735720B2
  申请人：——

  公开号：US8735720B2

  公开（公告）日：2014-05-27
• Discovery of new protein kinase CK2 inhibitors with 1,3-dioxo-2,3-dihydro-1H-indene core
  作者：Zong-liang Liu、Ren-mei Zhang、Qing-guo Meng、Xiao-chen Zhang、Yuan Sun

  DOI：10.1039/c6md00189k

  日期：——

  Protein kinase CK2 (CK2) serves as an attractive anticancer target. Herein new CK2 inhibitors with a 1,3-dioxo-2,3-dihydro-1H-indene core are reported.

  蛋白激酶CK2（CK2）作为一种具有吸引力的抗癌靶点。此处报道了具有1,3-二氧杂环-2,3-二氢-1H-茚核心的新型CK2抑制剂。