3-hydroxy-2-methylheptanoic acid | 80458-09-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3-hydroxy-2-methylheptanoic acid
• CAS: 80458-09-9
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: VBFGDSCDTYAEBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl 3-hydroxy-2-methylheptanoate 在 甲醇 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以28%的产率得到3-hydroxy-2-methylheptanoic acid
  参考文献：
  名称：

  Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated Sphaerimonospora mesophila

  摘要：

  Two new furanone-containing polyketides, linfuranones B and C, were isolated from a plant-associated actinomycete of the genus Sphaerimonospora. Their structures were determined by NMR and MS spectroscopic analyses, and the absolute configurations were established by anisotropic methods and chemical degradation approaches. In silico analysis of biosynthetic genes suggested that linfuranone B is generated from linfuranone C by oxidative cleavage of the polyketide chain. Linfuranones B and C induced preadipocyte differentiation into matured adipocytes at 20-40 mu M without showing cytotoxicity.

  DOI：

  10.1021/acs.jnatprod.8b00071

文献信息

• SYNTHESIS OF OLIGOKETIDES
  申请人：Kosan Biosciences

  公开号：EP1144375A2

  公开（公告）日：2001-10-17
• JPH0339094A
  申请人：——

  公开号：JPH0339094A

  公开（公告）日：1991-02-20
• US6225438B1
  申请人：——

  公开号：US6225438B1

  公开（公告）日：2001-05-01
• [EN] SYNTHESIS OF OLIGOKETIDES<br/>[FR] SYNTHESE DE POLYCETIDES
  申请人：KOSAN BIOSCIENCES INC

  公开号：WO2000044717A2

  公开（公告）日：2000-08-03

  Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as to form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.
• [EN] MEDIUM CHAIN LENGTH PHA COPOLYMER AND PROCESS FOR PRODUCING SAME<br/>[FR] COPOLYMERE PHA A LONGUEUR DE CHAINE MOYENNE ET PROCEDE DE PRODUCTION DE CELUI-CI
  申请人：PROCTER & GAMBLE

  公开号：WO2001055436A1

  公开（公告）日：2001-08-02

  Poly-3-hydroxyalkanoates (PHAs) that includes medium length 3-hydroxyacyl monomers and a process for producing the same comprising culturing a microorganism with a medium chain fatty carbon source and a fatty acid oxidation inhibitor. Using the process of this invention, microorganisms which normally incorporate only short chain fatty acids, produce PHAs containing short and medium chain 3-hydroxyacyl monomers.