8,8-difluorooctan-1-ol | 1311462-91-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8,8-difluorooctan-1-ol
• 英文别名: 8,8-Difluoro-1-octanol
• CAS: 1311462-91-5
• 化学式: C₈H₁₆F₂O
• 分子量: 166.211
• InChiKey: YGJVHSRYDOOIPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8,8-difluorooctan-1-ol 、 (R)-2-乙酰氧基-2-苯乙酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 生成
  参考文献：
  名称：

  Regio-selective hydroxylation of gem-difluorinated octanes by alkane hydroxylase (AlkB)

  摘要：

  gem-Difluoromethylene substituted molecules constitute a distinct class of fluorinated compounds. In this study, special chemistry has been developed for their preparation based on the highly selective terminal hydroxylation of these gem-difluorinated octanes by AlkB (alkane hydroxylase) from Pseudomonas putida Gpo1 to form gem-difluorinated octan-1-ols. The hydroxylation reaction is performed by whole-cell catalysis. Identification of the distal- and proximal-hydroxylation products was made by H-1, C-13, and F-19 NMR; GC and GC/MSD; and/or by comparison with authentic standards in GC. To the best of our knowledge, we have obtained the first synthesis of 2,2-, 3,3- and 4,4-difluorooctan-1-ols, from simple and inexpensive starting materials. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.03.101
• 作为产物：
  描述：

  正辛醛 在 [双(2-甲氧基乙基)胺]三氟化硫 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 8,8-difluorooctan-1-ol
  参考文献：
  名称：

  Regio-selective hydroxylation of gem-difluorinated octanes by alkane hydroxylase (AlkB)

  摘要：

  gem-Difluoromethylene substituted molecules constitute a distinct class of fluorinated compounds. In this study, special chemistry has been developed for their preparation based on the highly selective terminal hydroxylation of these gem-difluorinated octanes by AlkB (alkane hydroxylase) from Pseudomonas putida Gpo1 to form gem-difluorinated octan-1-ols. The hydroxylation reaction is performed by whole-cell catalysis. Identification of the distal- and proximal-hydroxylation products was made by H-1, C-13, and F-19 NMR; GC and GC/MSD; and/or by comparison with authentic standards in GC. To the best of our knowledge, we have obtained the first synthesis of 2,2-, 3,3- and 4,4-difluorooctan-1-ols, from simple and inexpensive starting materials. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.03.101

文献信息

• COMPOSITION FOR ABSORPTION REFRIGERATOR
  申请人：SANYO ELECTRIC CO., LTD.

  公开号：EP0048281A1

  公开（公告）日：1982-03-31

  A composition for an absorption refrigerator, which contains at least one fluorinated alcohol refrigerant containing 2 to 10 carbon atoms, is liquid at ordinary temperature, and becomes volatile upon heating under ordinary or reduced pressure, and at least one absorbent having a higher boiling point than said refrigerant at ordinary pressure and being capable of absorbing said refrigerant; and an absorption-refrigerating system using said composition.

  一种用于吸收式制冷机的组合物，它包含至少一种含 2 至 10 个碳原子的氟化醇制冷剂，在常温下为液态，在常压或减压下加热时变为挥发性，以及至少一种吸收剂，在常压下其沸点高于所述制冷剂，并能吸收所述制冷剂；以及一种使用所述组合物的吸收式制冷系统。
• US4455247A
  申请人：——

  公开号：US4455247A

  公开（公告）日：1984-06-19
• Regio-selective hydroxylation of gem-difluorinated octanes by alkane hydroxylase (AlkB)
  作者：Ravirala Ramu、Chun-Wei Chang、Ho-Husan Chou、Li-Lan Wu、Chih-Hsiang Chiang、Steve S.-F. Yu

  DOI：10.1016/j.tetlet.2011.03.101

  日期：2011.6

  gem-Difluoromethylene substituted molecules constitute a distinct class of fluorinated compounds. In this study, special chemistry has been developed for their preparation based on the highly selective terminal hydroxylation of these gem-difluorinated octanes by AlkB (alkane hydroxylase) from Pseudomonas putida Gpo1 to form gem-difluorinated octan-1-ols. The hydroxylation reaction is performed by whole-cell catalysis. Identification of the distal- and proximal-hydroxylation products was made by H-1, C-13, and F-19 NMR; GC and GC/MSD; and/or by comparison with authentic standards in GC. To the best of our knowledge, we have obtained the first synthesis of 2,2-, 3,3- and 4,4-difluorooctan-1-ols, from simple and inexpensive starting materials. (C) 2011 Elsevier Ltd. All rights reserved.