2-chloro-3-hydroxy-N,N-di(propan-2-yl)decanamide | 500208-70-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-chloro-3-hydroxy-N,N-di(propan-2-yl)decanamide
• CAS: 500208-70-8
• 化学式: C₁₆H₃₂ClNO₂
• 分子量: 305.889
• InChiKey: WIMAXUPGQWZYNJ-UHFFFAOYSA-N

物化性质

• 沸点：
  398.1±32.0 °C(Predicted)
• 密度：
  0.995±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二碘甲烷 、 2-chloro-3-hydroxy-N,N-di(propan-2-yl)decanamide 在 三氢化钐 作用下， 以 四氢呋喃 为溶剂， 以96%的产率得到trans-N,N-diisopropyl-2-heptylcyclopropanecarboxamide
  参考文献：
  名称：

  Sequential Elimination−Cyclopropanation Reactions Promoted by Samarium:  Highly Diastereoselective Synthesis of Cyclopropylamides

  摘要：

  trans-Cyclopropanamides were obtained, in high yield, from 2-chloro-3-hydroxyamides by a sequenced elimination-cyclopropanation process promoted by Samarium/diiodomethane or Samarium diiodide and Samarium/diiodomethane.

  DOI：

  10.1021/jo0262098
• 作为产物：
  描述：

  正辛醛 、 N,N-二异丙基氯乙酰胺 在 lithium diisopropyl amide 作用下， 生成 2-chloro-3-hydroxy-N,N-di(propan-2-yl)decanamide
  参考文献：
  名称：

  Sequential Elimination−Cyclopropanation Reactions Promoted by Samarium:  Highly Diastereoselective Synthesis of Cyclopropylamides

  摘要：

  trans-Cyclopropanamides were obtained, in high yield, from 2-chloro-3-hydroxyamides by a sequenced elimination-cyclopropanation process promoted by Samarium/diiodomethane or Samarium diiodide and Samarium/diiodomethane.

  DOI：

  10.1021/jo0262098

文献信息

• Sequential Elimination−Cyclopropanation Reactions Promoted by Samarium:  Highly Diastereoselective Synthesis of Cyclopropylamides
  作者：José M. Concellón、Humberto Rodríguez-Solla、Ricardo Llavona

  DOI：10.1021/jo0262098

  日期：2003.2.1

  trans-Cyclopropanamides were obtained, in high yield, from 2-chloro-3-hydroxyamides by a sequenced elimination-cyclopropanation process promoted by Samarium/diiodomethane or Samarium diiodide and Samarium/diiodomethane.