2-酮基-3-脱氧辛酮酸铵盐 | 1069-03-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-酮基-3-脱氧辛酮酸铵盐
• 中文别名: 3-脱氧辛酮糖酸铵盐
• 英文名称: 4,5,6,7,8-Pentahydroxy-2-oxooctanoic acid
• CAS: 1069-03-0
• 化学式: C₈H₁₄O₈
• 分子量: 238.19
• InChiKey: KYQCXUMVJGMDNG-UHFFFAOYSA-N

物化性质

• 沸点：
  621.7±55.0 °C(Predicted)
• 密度：
  1.684±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  156
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• ENZYMATIC METHOD FOR PREPARATION OF CMP-NEU5AC
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3892731A1

  公开（公告）日：2021-10-13

  The present invention relates to a method for producing cytidine 5'-monophospho-N-acetyl-neuraminic acid (CMP-Neu5Ac, 1) from low-cost substrates N-acetyl-D-glucosamine (GlcNAc), pyruvate, cytidine and polyphosphate in a single reaction mixture with a set of optionally immobilized or optionally co-immobilized enzymes comprising N-acylglucoamine 2-epimerase (AGE), an N-acetylneuraminate lyase (NAL), an N-acylneuraminate cytidylyltransferase (CSS), a uridine kinase (UDK), a uridine monophosphate kinase and a polyphosphate kinase 3 (PPK3). Further, said process may be adapted to produce Neu5Acylated i.e. sialylated biomolecules and biomolecules including a saccharide, a peptide, a protein, a glycopeptide, a glycoprotein, a glycolipid, a glycan, an antibody, and a glycoconjugate, in particular, an antibody drug conjugate, and a carbohydrate conjugate vaccine, or a flavonoid.

  本发明涉及一种用低成本底物N-乙酰-D-葡萄糖胺（GlcNAc）、丙酮酸、胞苷和多聚磷酸在单一反应混合物中生产胞苷-5'-单磷酸-N-乙酰-神经氨酸（CMP-Neu5Ac，1）的方法、在单一反应混合物中与一组可选固定化或可选共同固定化的酶进行反应，这些酶包括 N-乙酰葡糖胺 2-酰亚胺酶（AGE）、N-乙酰神经氨酸裂解酶（NAL）、N-乙酰神经氨酸胞苷酸转移酶（CSS）、尿苷激酶（UDK）、单磷酸尿苷激酶和多磷酸激酶 3（PPK3）。此外，所述工艺还可用于生产 Neu5Acylated 即糖醛酸化的生物大分子和生物大分子，包括糖、肽、蛋白质、糖肽、糖蛋白、糖脂、聚糖、抗体和糖共轭物，特别是抗体药物共轭物和碳水化合物共轭疫苗或黄酮类化合物。
• LOW MOLECULAR WEIGHT PECTIN COLUMN FOR APHERESIS
  申请人：ELIAZ ISAAC

  公开号：US20200360590A1

  公开（公告）日：2020-11-19

  An apheresis column for the treatment of mammals to reduce galectin-3 levels is set forth. The column features, as a stationary or adsorbent phase, pectin molecules, which naturally bind gal-3. Modified citrus pectin, having a molecular weight of about 40 kD or less, preferably about 25 kD or less, is a preferred adsorbent. The columns are disposable, and are used in the fashion for apheresis in general. Other targets, particularly including other galectins, as well as toxins, heavy metals and the like may also be withdrawn from the blood or plasma through this method. Gal-3 level reductions of 10%, 30% and even more may be achieved in a single treatment.
• [EN] LIVE SALMONELLA TYPHI VECTORS ENGINEERED TO EXPRESS CANCER PROTEIN ANTIGENS AND METHODS OF USE THEREOF<br/>[FR] VECTEURS VIVANTS DE SALMONELLA TYPHI MODIFIÉS POUR EXPRIMER DES ANTIGÈNES DE PROTÉINES CANCÉREUSES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV MARYLAND

  公开号：WO2021178888A1

  公开（公告）日：2021-09-10

  The present invention provides compositions and methods for inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector, wherein the Salmonella Typhi vector has been engineered to express one or more cancer antigens. In some aspects the vector has been engineered to express an outer membrane folding protein Bam A or a fragment or variant thereof; and a lipid A deacylase PagL or a fragment or variant thereof, wherein the Salmonella Typhi vector is capable of delivering the antigen to a mucosal tissue or subcutaneously to dendritic cells via an outer membrane vesicle when administered to a subject.