N-(sec-butyl)-N-methylacrylamide | 57086-50-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(sec-butyl)-N-methylacrylamide
• 英文别名: (+/-)-N-(sec-Butyl)-N-methylacrylamid；N-(s-butyl)-N-methylacrylamide；N-butan-2-yl-N-methylprop-2-enamide
• CAS: 57086-50-7
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: WJZKJIRGNABOKB-UHFFFAOYSA-N

物化性质

• 沸点：
  231.9±9.0 °C(Predicted)
• 密度：
  0.880±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(sec-butyl)-N-methylacrylamide 在 sodium azide 、 溴 、 caesium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.0h， 生成 N-(sec-butyl)-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide
  参考文献：
  名称：

  Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides

  摘要：

  A series of 1-arylpyrrolo[1,2-a] pyrazine-3-carboxamides were designed and synthesized as 18 kDa translocator protein (TSPO) ligands. Anxiolytic-like activity of compounds was evaluated in the open field test and elevated plus maze test. Compounds 1a and 1b demonstrated high anxiolytic-like effect in the dose range of 0.1-1.0 mg/kg comparable with that of diazepam. The involvement of TSPO receptor in the mechanism of anxiolytic-like activity of new compounds was proved by antagonism of the most active compound 1a with TSPO selective inhibitor PK11195. In vitro binding studies demonstrated high TSPO affinities for compounds 1a and 1b. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.04.049
• 作为产物：
  描述：

  N-甲基异丁胺 、 丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以73%的产率得到N-(sec-butyl)-N-methylacrylamide
  参考文献：
  名称：

  Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides

  摘要：

  A series of 1-arylpyrrolo[1,2-a] pyrazine-3-carboxamides were designed and synthesized as 18 kDa translocator protein (TSPO) ligands. Anxiolytic-like activity of compounds was evaluated in the open field test and elevated plus maze test. Compounds 1a and 1b demonstrated high anxiolytic-like effect in the dose range of 0.1-1.0 mg/kg comparable with that of diazepam. The involvement of TSPO receptor in the mechanism of anxiolytic-like activity of new compounds was proved by antagonism of the most active compound 1a with TSPO selective inhibitor PK11195. In vitro binding studies demonstrated high TSPO affinities for compounds 1a and 1b. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.04.049

文献信息

• High temperature fracturing fluids with nanoparticles
  申请人：Saudi Arabian Oil Company

  公开号：US10550314B2

  公开（公告）日：2020-02-04

  Embodiments for a high temperature fracturing fluid comprise an aqueous fluid, carboxyl-containing synthetic polymer, metal oxide nanoparticles having a particle size of 0.1 to 500 nanometers, and a metal crosslinker which crosslinks the carboxyl-containing synthetic polymers to form a crosslinked gel, wherein the metal oxide nanoparticles are dispersed within the crosslinked gel.

  高温压裂液的实施方案包括水性流体、含羧基的合成聚合物、粒径为 0.1 至 500 纳米的金属氧化物纳米颗粒，以及将含羧基的合成聚合物交联以形成交联凝胶的金属交联剂，其中金属氧化物纳米颗粒分散在交联凝胶中。
• HIGH TEMPERATURE FRACTURING FLUIDS WITH NANOPARTICLES
  申请人：Saudi Arabian Oil Company

  公开号：EP3331964B1

  公开（公告）日：2021-06-30
• MULTI-COMPONENT AQUEOUS GEL SOLUTION FOR CONTROL OF DELAYED GELATION TIMING AND FOR RESULTING GEL PROPERTIES
  申请人：BURNS LYLE D.

  公开号：US20080125334A1

  公开（公告）日：2008-05-29

  A water based solution having a controllable gel time is disclosed. The solution has predetermined ratios of a water soluble silicate solution having at least one alkali metal, a predetermined ratio of a water dispersible polymer, and a predetermined ratio of a water soluble initiator containing a reactive carbonyl compound.
• METHODS OF MAKING HYDRAULIC FRACTURING FLUIDS AND USE THEREOF
  申请人：Saudi Arabian Oil Company

  公开号：US20210403799A1

  公开（公告）日：2021-12-30

  Methods of preparing a crosslinked hydraulic fracturing fluid include combining a hydraulic fracturing fluid comprising a polyacrylamide polymer with a plurality of coated proppants. The plurality of coated proppants include a proppant particle and a resin proppant coating on the proppant particle. The resin proppant coating includes resin and a zirconium oxide crosslinker. The resin includes at least one of phenol, furan, epoxy, urethane, phenol-formaldehyde, polyester, vinyl ester, and urea aldehyde. Methods further include allowing the zirconium oxide crosslinker within the resin proppant coating to crosslink the polyacrylamide polymer within the hydraulic fracturing fluid at a pH of at least 10, thereby forming the crosslinked hydraulic fracturing fluid.
• US4040484A
  申请人：——

  公开号：US4040484A

  公开（公告）日：1977-08-09