2,3,4,5-Tetrahydro-5-oxo-2-phenyl-3-furancarbonsaeure-methylester | 13389-99-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2,3,4,5-Tetrahydro-5-oxo-2-phenyl-3-furancarbonsaeure-methylester
• 英文别名: 5-oxo-2-phenyl-tetrahydro-furan-3-carboxylic acid methyl ester；5-Oxo-2-phenyl-tetrahydro-furan-3-carbonsaeure-methylester；Methyl 5-oxo-2-phenyloxolane-3-carboxylate
• CAS: 13389-99-6
• 化学式: C₁₂H₁₂O₄
• 分子量: 220.225
• InChiKey: UTMMTSFNCUGDPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-Cyan-2-(1'-phenyl-1'-trimethylsilyloxymethyl)-4-trimethylsilyloxy-3-butensaeure-methylester 在 盐酸 作用下， 以71%的产率得到2,3,4,5-Tetrahydro-5-oxo-2-phenyl-3-furancarbonsaeure-methylester
  参考文献：
  名称：

  Huenig, Siegfried; Schaefer, Matthias, Chemische Berichte, 1993, vol. 126, # 1, p. 177 - 190

  摘要：

  DOI：

文献信息

• Barbier; Locquin, Bulletin de la Societe Chimique de France, 1913, vol. <4> 13, p. 226
  作者：Barbier、Locquin

  DOI：——

  日期：——
• [EN] MAX BINDERS AS MYC MODULATORS AND USES THEREOF<br/>[FR] LIANTS DE MAX COMME MODULATEURS DE MYC ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2017143059A1

  公开（公告）日：2017-08-24

  The present disclosure provides compounds of Formula (I'), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described herein are MAX binders and/or modulators of Myc, Mad, or Mxi1 (e.g., inhibitors of Myc, Mad, or Mxi1), and may be useful in treating a subject with a disease associated with Myc, such as proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions and kits including the compounds described herein, as well as methods of using and uses of the compounds, compositions, and kits.
• Huenig, Siegfried; Schaefer, Matthias, Chemische Berichte, 1993, vol. 126, # 1, p. 177 - 190
  作者：Huenig, Siegfried、Schaefer, Matthias

  DOI：——

  日期：——

表征谱图