2″-O-没食子酰基槲皮苷 | 80229-08-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 2″-O-没食子酰基槲皮苷
• 英文名称: quercetin-3-O-(2''-O-galloyl)-α-L-rhamnoside
• 英文别名: quercetin-3-O-(2"-O-galloyl)-α-L-rhamnopyranoside；quercetin-3-O-(2″-O-galloyl)-α-L-rhamnoside；2''-O-Galloylquercitrin；[(2S,3R,4R,5R,6S)-2-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-4,5-dihydroxy-6-methyloxan-3-yl] 3,4,5-trihydroxybenzoate
• CAS: 80229-08-9
• 化学式: C₂₈H₂₄O₁₅
• 分子量: 600.49
• InChiKey: KTTNFIOZYNBKEY-YIOJSCHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  43
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  253
• 氢给体数：
  9
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  2″-O-没食子酰基槲皮苷 在 ammonium hydroxide 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 槲皮苷
  参考文献：
  名称：

  Flavonoids ofPolygonumsieboldiandP.filiforme

  摘要：

  从Polygonum sieboldi和P. filiforme中分离出五种含有新型黄酮苷的黄酮类化合物。根据化学和光谱数据，确定新化合物的结构为槲皮素3-鼠李糖苷2″-没食子酸酯。

  DOI：

  10.1246/bcsj.54.3239

文献信息

• METHODS OF PREVENTING TUMOR METASTASIS, TREATING AND PROGNOSING CANCER AND IDENTIFYING AGENTS WHICH ARE PUTATIVE METASTASIS INHIBITORS
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US20150290233A1

  公开（公告）日：2015-10-15

  A method of preventing tumor metastasis with the proviso that the tumor is not glioma is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2), thereby preventing tumor metastasis. Also, provided is a method of treating cancer. The method comprising, administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2) and an inhibitor of a cell surface receptor associated with an onset or progression of cancer, thereby treating cancer.
• SYNAPTOJANIN-2 INHIBITORS FOR USE IN THE TREATMENT OF CANCER
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20170042857A1

  公开（公告）日：2017-02-16

  Disclosed herein are synaptojanin-2 inhibitors, and novel methods and uses utilizing same for preventing tumor metastasis, treating cancer or inhibiting synaptojanin-2. Compounds disclosed herein include chlorhexidine and pyrvinium, the compound having the formula: and compounds characterized by the general formula: X-L-[(Y)i-(Z)j]-(L-X)k and/or by the general formula: wherein L, X, Y, Z, D, E, i, j and k are as defined herein.
• [EN] METHODS OF PREVENTING TUMOR METASTASIS, TREATING AND PROGNOSING CANCER AND IDENTIFYING AGENTS WHICH ARE PUTATIVE METASTASIS INHIBITORS<br/>[FR] MÉTHODES DE PRÉVENTION D'UNE MÉTASTASE TUMORALE, DE TRAITEMENT ET DE PRONOSTIC DU CANCER, ET D'IDENTIFICATION D'AGENTS SUSCEPTIBLES DE CONSTITUER DES INHIBITEURS DE MÉTASTASE
  申请人：YEDA RES & DEV

  公开号：WO2014083567A2

  公开（公告）日：2014-06-05

  A method of preventing tumor metastasis with the proviso that the tumor is not glioma is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2), thereby preventing tumor metastasis. Also, provided is a method of treating cancer. The method comprising, administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2) and an inhibitor of a cell surface receptor associated with an onset or progression of cancer, thereby treating cancer.
• [EN] SYNAPTOJANIN-2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE SYNAPTOJANINE-2 ET LEURS UTILISATIONS
  申请人：YEDA RES & DEV

  公开号：WO2015079413A2

  公开（公告）日：2015-06-04

  Disclosed herein are synaptojanin-2 inhibitors, and novel methods and uses utilizing same for preventing tumor metastasis, treating cancer or inhibiting synaptojanin-2. Compounds disclosed herein include chlorhexidine and pyrvinium, the compound having the formula: (I) and compounds characterized by the general formula: X-L-[(Y)i-(Z)j]-(L-X)k and/or by the general formula:(II) wherein L, X, Y, Z, D, E, i, j and k are as defined herein.