3,6,9,12,15-Pentaoxaoctadecan-1-ol | 71563-45-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,6,9,12,15-Pentaoxaoctadecan-1-ol
• 英文别名: 2-[2-[2-[2-(2-propoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
• CAS: 71563-45-6
• 化学式: C₁₃H₂₈O₆
• 分子量: 280.36
• InChiKey: HFXJSFXYJFCTSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  19
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• System for delivering therapeutic agents into living cells and cells nuclei
  申请人：Segev David

  公开号：US20080004234A1

  公开（公告）日：2008-01-03

  A novel class of oligomeric compounds designed for forming conjugates with biologically active substances and delivering these substances to a desired bodily target are disclosed. Novel conjugates of these oligomeric compounds and biologically active moieties, pharmaceutical compositions containing such conjugates, and uses thereof as delivery systems for delivering the biologically active substances to a desired target are further disclosed. Processes of preparing the conjugates and the oligomeric compounds and novel intermediates designed for and used in these processes are also disclosed.

  本发明揭示了一类新型的寡聚化合物，旨在与生物活性物质形成共轭物，并将这些物质传递到所需的身体靶点。本发明还揭示了这些寡聚化合物与生物活性物质的新型共轭物，含有这种共轭物的制药组合物，以及将其用作传递生物活性物质到所需目标的传递系统的用途。本发明还揭示了制备这些共轭物和寡聚化合物的过程以及设计和用于这些过程的新型中间体。
• Selective and Specific Preparation of Discrete Peg Compounds
  申请人：Davis Paul D.

  公开号：US20110124844A1

  公开（公告）日：2011-05-26

  Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods which can be used to build up larger dPEG compounds (a) containing a wider range of utility to make useful homo- and heterofunctional and branched species, and (b) under reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date. In addition, the embodiments of the invention allow for processes that allow for significantly improving the ability to purify the intermediates or final product mixtures, making these methods useful for commerial manufacturing dPEGs. Protecting groups and functional groups can be designed to make purification at large scale a practical reality. The novel dPEG products form the compositional and material basis for making other novel compounds of valuable application in the fields of diagnostics and therapeutics, amongst others.

  本发明的方面是针对制备离散聚乙烯化合物的新方法，可以有选择地和特定地制备出预定数量的氧化乙烯单元。这些方法可以用于构建更大的dPEG化合物（a），其中包含更广泛的实用性，以制备有用的同、异功能性和分支物种，以及（b）在反应配置和条件下，这些条件比迄今为止报道的任何传统方法更温和、更高效、更多样化，更具有控制性和更具有多功能性。此外，本发明的实施例允许进行显著提高中间体或最终产物混合物纯化能力的过程，使这些方法对于商业生产dPEGs非常有用。保护基和功能基可以设计成使大规模纯化成为现实。新型dPEG产品形成了用于制备其他有价值应用于诊断和治疗等领域的新型化合物的组成和材料基础。
• Vapor phase soldering using certain perfluorinated polyethers
  申请人：Monsanto Company

  公开号：EP0326539A1

  公开（公告）日：1989-08-02

  A perfluorinated polyether having the formula RfO-(CF₂CF₂O)n-R′f wherein n=3-11 and Rf and Rf′ are perfluroinated C₁-C₅ alkyl radicals is used in vapor phase soldering applications. Especially useful for such applications is perfluoroheptaglyme.

  全氟聚醚具有 RfO-(CF₂-CF₂O)n-R′f，其中 n=3-11 和 Rf 和 Rf′是全氟 C₁-C₅烷基，可用于气相焊接。尤其适用于此类应用的是全氟庚二酸。
• Novel perfluorinated polyethers and process for their preparation
  申请人：Monsanto Company

  公开号：EP0332601A1

  公开（公告）日：1989-09-13

  Perfluorinated polyethers having the formula RfO-(CF₂CF₂O)n-R′f wherein n is an integer of 1-11 and each of Rf and R′f is a perfluorinated C₁-C₅-alkyl radical, dimers of such polyethers and carbon to carbon intra­molecularly coupled cyclic derivatives of such poly­ethers are produced by direct fluorination of the polyethers in an inert solvent. Compositions of the perfluorinated polyethers and their derivatives are useful as functional fluids.

  全氟聚醚，其化学式为 RfO-(CF₂CF₂O)n-R′f 其中 n 为 1-11 的整数，Rf 和 R′f 各为全氟 C₁-C₅-烷基，此类聚醚的二聚体以及此类聚醚的碳-碳分子内偶联环状衍生物是通过在惰性溶剂中直接氟化聚醚制得的。全氟聚醚及其衍生物的组合物可用作功能性液体。
• Water-absorptive contact lens and method of producing the same
  申请人：Menicon Co., Ltd.

  公开号：EP1378769A2

  公开（公告）日：2004-01-07

  A water-absorptive contact lens whose water content is in a range from 10% to 60% and which is formed of a polymeric material obtained by copolymerization of a polymerizable monomer composition that includes: (A) 20 to 70 wt.% of alkoxypolyethylene glycol (meth)acrylate having at least three ethylene glycol units, and (B) 30 to 80 wt.% of a silicon-containing macromonomer.

  一种吸水性隐形眼镜，其含水量在 10%至 60%之间，由可聚合单体组合物共聚而成的聚合材料形成，该单体组合物包括：(A) 20 至 70 重量％的具有至少三个乙二醇单元的烷氧基聚乙二醇（甲基）丙烯酸酯，和 (B) 30 至 80 重量％的硅：(A)20-70重量％的烷氧基聚乙二醇（甲基）丙烯酸酯，至少有三个乙二醇单元，和(B)30-80重量％的含硅大单体。