(1R)-1-(6-hydrazino-purin-9-yl)-1,4-anhydro-ribitol | 5746-27-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (1R)-1-(6-hydrazino-purin-9-yl)-1,4-anhydro-ribitol
• 英文别名: (1R)-1-(6-Hydrazino-purin-9-yl)-1,4-anhydro-ribit；(3R,4S,5R)-2-(6-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 5746-27-0；65177-90-4
• 化学式: C₁₀H₁₄N₆O₄
• 分子量: 282.259
• InChiKey: DGKZTAGCCXJUAT-VTHZCTBJSA-N

物化性质

• 沸点：
  761.6±70.0 °C(Predicted)
• 密度：
  2.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  152
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• NOVEL HYDRAZONE DERIVATIVES HAVING POTENT ANTITUMOR ACTIVITY TOWARD MULTI-DRUG RESISTANT TUMOR CELLS
  申请人：JAYARAM Hiremagular N.

  公开号：US20120329747A1

  公开（公告）日：2012-12-27

  A patentable new class of hydrazone derivative compounds is described, as are methods for synthesizing such compounds. The hydrazones of the invention can be used, for example, as potent anti-cancer agents, including to inhibit the growth of cancer cells that exhibit multidrug resistance.
• US9133230B2
  申请人：——

  公开号：US9133230B2

  公开（公告）日：2015-09-15