3,3-二甲基-1-(2-甲基苯基)-1-丁酮 | 898785-47-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3,3-二甲基-1-(2-甲基苯基)-1-丁酮
• 英文名称: 2',3,3-Trimethylbutyrophenone
• 英文别名: 3,3-dimethyl-1-(2-methylphenyl)butan-1-one
• CAS: 898785-47-2
• 化学式: C₁₃H₁₈O
• 分子量: 190.28
• InChiKey: VMITUSFJYSOWOE-UHFFFAOYSA-N

物化性质

• 沸点：
  267.8±9.0 °C(Predicted)
• 密度：
  0.935±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914399090

文献信息

• Novel amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
  申请人：Bolea Christelle

  公开号：US20110257182A1

  公开（公告）日：2011-10-20

  The present invention relates to novel compounds of Formula (I), wherein X 1 , X 2 , X 3 , X 4 , A m and B n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.

  本发明涉及一种新型的化合物，其化学式为(I)，其中X1、X2、X3、X4、A和Bn的定义如化学式(I)中所示；发明的化合物是代谢型谷氨酸受体亚型4（“mGluR4”）的调节剂，可用于治疗或预防中枢神经系统疾病以及其他由mGluR4受体调节的疾病。本发明还涉及制药组合物以及使用这些化合物制备药物的方法，以及使用这些化合物预防和治疗涉及mGluR4的疾病的方法。
• NOVEL AMIDO DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Addex Pharma, SA

  公开号：US20130137704A1

  公开（公告）日：2013-05-30

  The present invention relates to novel compounds of Formula (I), wherein X 1 , X 2 , X 3 , X 4 , A m and B n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.

  本发明涉及公式（I）的新化合物，其中X1，X2，X3，X4，A和Bn如公式（I）所定义；发明化合物是代谢型谷氨酸受体-亚型4（“mGluR4”）的调节剂，可用于治疗或预防中枢神经系统疾病以及其他受mGluR4受体调节的疾病。本发明还涉及制药组合物以及使用此类化合物制造药物的用途，以及使用此类化合物预防和治疗涉及mGluR4的疾病的用途。
• Novel lipopeptides as antibacterial agents
  申请人：Hill Jason

  公开号：US20050203006A1

  公开（公告）日：2005-09-15

  The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.

  本发明涉及新型脂肽化合物。本发明还涉及这些化合物的药物组合物以及将这些化合物用作抗菌化合物的方法。本发明还涉及生产这些新型脂肽化合物和用于生产这些化合物的中间体的方法。
• COMPOSITION AND POLYMER
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP2735581B1

  公开（公告）日：2021-07-14
• Composition and Polymer
  申请人：Nakamura Akitake

  公开号：US20140121293A1

  公开（公告）日：2014-05-01

  Disclosed is a composition comprising (A) at least one compound selected from the group consisting of an ether compound having two or more ether groups, a trivalent phosphorus compound, and a ketone compound, (B) a boron trihalide, and (C) an episulfide compound.