2-(1-(4-chlorophenyl)-3-oxo-3-phenylpropyl)-2H-indene-1,3-dione | 16270-70-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(1-(4-chlorophenyl)-3-oxo-3-phenylpropyl)-2H-indene-1,3-dione
• 英文别名: 2-<2-Benzoyl-1-(p-chlorphenyl)-ethyl>-indandion-(1.3)；2-[2-Benzoyl-1-(p-chlorphenyl)-ethyl]-indandion-(1.3)；2-[1-(4-Chlorophenyl)-3-oxo-3-phenylpropyl]indene-1,3-dione
• CAS: 16270-70-5
• 化学式: C₂₄H₁₇ClO₃
• 分子量: 388.85
• InChiKey: BLAGQYQEJUHJCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  51.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(1-(4-chlorophenyl)-3-oxo-3-phenylpropyl)-2H-indene-1,3-dione 在 一水合肼 作用下， 反应 0.33h， 以95%的产率得到5-(4-chlorophenyl)-3-phenyl-4,5-dihydroindeno[1,2-c][1,2]diazepin-6(1H)-one
  参考文献：
  名称：

  A Novel and Highly Efficient Protocol for the Synthesis of Chalcone Based 1,2-Diazepine and 1,2-Oxazepine Derivatives

  摘要：

  A novel and highly efficient protocol is described for the synthesis of chalcone based 1,2-diazepine and I,2-oxazepine derivatives. Under neat condition, the mixing and grinding of 1,5-diketones and hydrazine gave the cyclocondensation products in quantitative yields within 10-20 min at room temperature. Similarly, novel chalcone based 1,2-oxazepines were synthesized in excellent yields (85-88%) in 2-3 h at refluxed by the condensation of 1,5-diktones and hydroxylamine hydrochloride in water-ethanolic base.

  DOI：

  10.3987/com-12-12444
• 作为产物：
  描述：

  4-氯查耳酮 、 1,3-茚满二酮 在 potassium carbonate 作用下， 以 乙酸乙酯 为溶剂， 以90%的产率得到2-(1-(4-chlorophenyl)-3-oxo-3-phenylpropyl)-2H-indene-1,3-dione
  参考文献：
  名称：

  A Novel and Highly Efficient Protocol for the Synthesis of Chalcone Based 1,2-Diazepine and 1,2-Oxazepine Derivatives

  摘要：

  A novel and highly efficient protocol is described for the synthesis of chalcone based 1,2-diazepine and I,2-oxazepine derivatives. Under neat condition, the mixing and grinding of 1,5-diketones and hydrazine gave the cyclocondensation products in quantitative yields within 10-20 min at room temperature. Similarly, novel chalcone based 1,2-oxazepines were synthesized in excellent yields (85-88%) in 2-3 h at refluxed by the condensation of 1,5-diktones and hydroxylamine hydrochloride in water-ethanolic base.

  DOI：

  10.3987/com-12-12444

文献信息

• BEHERA R. K.; NAYAK A., INDIAN J. CHEM. <IJOC-AP>, 1976, B 14, NO 3, 223-224
  作者：BEHERA R. K.、 NAYAK A.

  DOI：——

  日期：——
• A Novel and Highly Efficient Protocol for the Synthesis of Chalcone Based 1,2-Diazepine and 1,2-Oxazepine Derivatives
  作者：Naseem Ahmed、B. Venkata Babu

  DOI：10.3987/com-12-12444

  日期：——

  A novel and highly efficient protocol is described for the synthesis of chalcone based 1,2-diazepine and I,2-oxazepine derivatives. Under neat condition, the mixing and grinding of 1,5-diketones and hydrazine gave the cyclocondensation products in quantitative yields within 10-20 min at room temperature. Similarly, novel chalcone based 1,2-oxazepines were synthesized in excellent yields (85-88%) in 2-3 h at refluxed by the condensation of 1,5-diktones and hydroxylamine hydrochloride in water-ethanolic base.