2-p-Toluidino-4-thiazolon-5-carboxamin | 65263-12-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-p-Toluidino-4-thiazolon-5-carboxamin
• 英文别名: 4-oxo-2-(4-methyl-anilino)-4,5-dihydro-thiazole-5-carboxylic acid amide；2-(4-Methylphenyl)imino-4-oxo-1,3-thiazolidine-5-carboxamide；2-(4-methylphenyl)imino-4-oxo-1,3-thiazolidine-5-carboxamide
• CAS: 65263-12-9
• 化学式: C₁₁H₁₁N₃O₂S
• 分子量: 249.293
• InChiKey: HSDHOCYPHWDLGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-acetylimino-4-amino-3-p-tolyl-2,3-dihydro-thiazole-5-carbonitrile 在 PPA 、 磷酸 作用下， 生成 2-p-Toluidino-4-thiazolon-5-carboxamin
  参考文献：
  名称：

  Singh,A.; Uppal,A.S., Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978, vol. 16, p. 779 - 781

  摘要：

  DOI：

文献信息

• New compounds
  申请人：Barf Tjeerd

  公开号：US20050239853A1

  公开（公告）日：2005-10-27

  The present invention relates to compounds with the formula (I) wherein R 1 , R 2 , R 3 , X, and Y are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-hydroxysteroid dehydrogenase type 1 enzyme.

  本发明涉及具有式（I）的化合物，其中R1，R2，R3，X和Y的定义如本文所述，以及包含该化合物的药物组合物，以及在医学上使用该化合物以及用于制备作用于人类11-羟基类固醇脱氢酶1型酶的药物的方法。
• [EN] THIAZOL-COMPOUNDS AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS<br/>[FR] COMPOSES THIAZOLE UTILISES EN TANT QU'INHIBITEURS DE LA 11-BETA-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1
  申请人：BIOVITRUM AB

  公开号：WO2005075471A2

  公开（公告）日：2005-08-18

  The present invention relates to compounds with the formula (I), wherein R1, R2, R3, X, and Y are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
• Singh,A.; Uppal,A.S., Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978, vol. 16, p. 779 - 781
  作者：Singh,A.、Uppal,A.S.

  DOI：——

  日期：——