5-(4-(trifluoromethoxy)benzyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-c]pyridine | 858935-16-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-(trifluoromethoxy)benzyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-c]pyridine
• 英文别名: 2-(2,3-Difluorophenyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazo[4,5-c]pyridine
• CAS: 858935-16-7
• 化学式: C₂₀H₁₂F₅N₃O
• 分子量: 405.327
• InChiKey: QTYBVTHJXSKUBV-UHFFFAOYSA-N

物化性质

• 沸点：
  430.4±55.0 °C(Predicted)
• 密度：
  1.41±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-(2,3-二氟苯基)-1H-咪唑并[4,5-c]吡啶 、 4-三氟甲氧基氯苄 在 sodium hydroxide 作用下， 以 DMF (N,N-dimethyl-formamide) 、 水 为溶剂， 反应 0.02h， 生成 5-(4-(trifluoromethoxy)benzyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-c]pyridine
  参考文献：
  名称：

  [EN] IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT
  [FR] COMPOSES D'IMIDAZO[4,5-C]PYRIDINE ET METHODES DE TRAITEMENT ANTIVIRAL

  摘要：

  公开号：

  WO2005063744A3

文献信息

• Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: Further optimization of anti-hepatitis C virus activity
  作者：Gerhard Puerstinger、Jan Paeshuyse、Susanne Heinrich、Joachim Mohr、Nicole Schraffl、Erik De Clercq、Johan Neyts

  DOI：10.1016/j.bmcl.2007.07.015

  日期：2007.9

  zo[4,5-c]pyridines represent a novel class of compounds with activity against pestiviruses and the hepatitis C virus (HCV). Several series of analogues with modifications of the substituents in positions 2 and 5 were prepared. These efforts resulted in the discovery of several compounds with potent antiviral activity of which 2-(2,3-difluorophenyl)-5-[4-(trifluoromethyl)benzyl]-5H-imidazo[4,5-c]pyridine

  取代的5-苄基-2-苯基-5H-咪唑并[4,5-c]吡啶代表了一类新的对瘟病毒和丙型肝炎病毒（HCV）具有活性的化合物。制备了几个在位置2和5上具有取代基修饰的类似物系列。这些努力导致发现了几种具有有效抗病毒活性的化合物，其中2-（2,3-二氟苯基）-5- [4-（三氟甲基）苄基] -5H-咪唑并[4,5-c]吡啶（46）对HCV最有效（EC（50）为0.10 microM，选择性指数为1080）。
• Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
  申请人：Bondy S. Steven

  公开号：US20050222198A1

  公开（公告）日：2005-10-06

  The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general formula (A): wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general formula and their use in the treatment or prophylaxis of viral infections.

  本发明涉及制备用于治疗或预防病毒感染的药物组合物，其包含至少一种具有通式（A）的咪唑[4,5-c]吡啶前药作为活性成分，其中取代基在规范中描述。本发明还涉及根据上述通式制备和筛选化合物的过程，以及它们在治疗或预防病毒感染中的用途。
• Imidazo 4,5-C Pyridine Compounds and Methods of Antiviral Treatment
  申请人：Bondy S. Steven

  公开号：US20070244148A1

  公开（公告）日：2007-10-18

  The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general formula (Z): The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula and their use as a medicine or to treat or prevent viral infections.

  本发明涉及一种用于治疗或预防病毒感染的药物组合物，其包含至少一种具有以下通式（Z）的咪唑[4,5-c]吡啶前药作为活性成分：本发明还涉及制备符合上述通式的化合物的方法以及它们作为药物或用于治疗或预防病毒感染的用途。
• IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT
  申请人：Bondy Steven S.

  公开号：US20100028301A1

  公开（公告）日：2010-02-04

  The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

  本发明涉及一种制备用于治疗或预防病毒感染的药物组合物，其包含至少一种咪唑并[4,5-c]吡啶前药作为活性成分，其通式为（A），其中取代基在规范中描述。该发明还涉及根据上述通式制备和筛选化合物的方法以及它们在治疗或预防病毒感染中的应用。
• Imidazo 4,5-c pyridine compounds and methods of antiviral treatment
  申请人：K.U. Leuven Research & Development

  公开号：US07648998B2

  公开（公告）日：2010-01-19

  The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening ofcompounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

  本发明涉及一种用于治疗或预防病毒感染的药物组合物，其包括至少一种咪唑[4,5-c]吡啶前药作为活性成分，其通式为（A），其中取代基在说明书中描述。本发明还涉及根据上述通式制备和筛选化合物的方法，以及它们在治疗或预防病毒感染中的用途。