(E)-4-(6-methoxy-7-methyl-3-oxo-4-((2-(trimethylsilyl)ethoxy)-methoxy)-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enal | 1229030-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: (E)-4-(6-methoxy-7-methyl-3-oxo-4-((2-(trimethylsilyl)ethoxy)-methoxy)-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enal
• 英文别名: (E)-4-[6-methoxy-7-methyl-3-oxo-4-(2-trimethylsilylethoxymethoxy)-1H-2-benzofuran-5-yl]-2-methylbut-2-enal
• CAS: 1229030-09-4
• 化学式: C₂₁H₃₀O₆Si
• 分子量: 406.551
• InChiKey: AXEXAVIXMJCAFH-VGOFMYFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.05
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (E)-4-(6-methoxy-7-methyl-3-oxo-4-((2-(trimethylsilyl)ethoxy)-methoxy)-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enal 在 sodium tetrahydroborate 、 cerium(III) chloride heptahydrate 、 盐酸 作用下， 以 甲醇 、 水 、 乙酸乙酯 为溶剂， 以57%的产率得到(E)-6-(4-hydroxy-3-methylbut-2-en-1-yl)-5-methoxy-4-methyl-7-((2-(trimethylsilyl)ethoxy)methoxy)isobenzofuran-1(3H)-one
  参考文献：
  名称：

  Triazole-Linked Inhibitors of Inosine Monophosphate Dehydrogenase from Human and Mycobacterium tuberculosis

  摘要：

  The modular nature of nicotinamide adenine dinucleotide (NAD)-mimicking inosine monophsophate dehydrogenase (IMPDH) inhibitors has prompted us to investigate novel mycophenolic adenine dinucleotides (MAD) in which 1,2,3-triazole linkers were incorporated as isosteric replacements of the pyrophosphate linker. Synthesis and evaluation of these inhibitors led to identification of low nanomolar inhibitors of human IMPDH and more importantly the first potent inhibitor of IMPDH from Mycobacterium tuberculosis (mtIMPDH). Computational studies of these IMPDH enzymes helped rationalize the observed structure-activity relationships. Additionally, the first cloning, expression, purification and characterization of mtIMPDH is reported.

  DOI：

  10.1021/jm100424m
• 作为产物：
  描述：

  (E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enal 、 2-(三甲基硅烷基)乙氧甲基氯 在 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.33h， 以88%的产率得到(E)-4-(6-methoxy-7-methyl-3-oxo-4-((2-(trimethylsilyl)ethoxy)-methoxy)-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enal
  参考文献：
  名称：

  Triazole-Linked Inhibitors of Inosine Monophosphate Dehydrogenase from Human and Mycobacterium tuberculosis

  摘要：

  The modular nature of nicotinamide adenine dinucleotide (NAD)-mimicking inosine monophsophate dehydrogenase (IMPDH) inhibitors has prompted us to investigate novel mycophenolic adenine dinucleotides (MAD) in which 1,2,3-triazole linkers were incorporated as isosteric replacements of the pyrophosphate linker. Synthesis and evaluation of these inhibitors led to identification of low nanomolar inhibitors of human IMPDH and more importantly the first potent inhibitor of IMPDH from Mycobacterium tuberculosis (mtIMPDH). Computational studies of these IMPDH enzymes helped rationalize the observed structure-activity relationships. Additionally, the first cloning, expression, purification and characterization of mtIMPDH is reported.

  DOI：

  10.1021/jm100424m

文献信息

• Triazole-Linked Inhibitors of Inosine Monophosphate Dehydrogenase from Human and <i>Mycobacterium tuberculosis</i>
  作者：Liqiang Chen、Daniel J. Wilson、Yanli Xu、Courtney C. Aldrich、Krzysztof Felczak、Yuk Y. Sham、Krzysztof W. Pankiewicz

  DOI：10.1021/jm100424m

  日期：2010.6.24

  The modular nature of nicotinamide adenine dinucleotide (NAD)-mimicking inosine monophsophate dehydrogenase (IMPDH) inhibitors has prompted us to investigate novel mycophenolic adenine dinucleotides (MAD) in which 1,2,3-triazole linkers were incorporated as isosteric replacements of the pyrophosphate linker. Synthesis and evaluation of these inhibitors led to identification of low nanomolar inhibitors of human IMPDH and more importantly the first potent inhibitor of IMPDH from Mycobacterium tuberculosis (mtIMPDH). Computational studies of these IMPDH enzymes helped rationalize the observed structure-activity relationships. Additionally, the first cloning, expression, purification and characterization of mtIMPDH is reported.