3-(4-phenyloxazol-2-yl)pyridine | 504415-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4-phenyloxazol-2-yl)pyridine
• 英文别名: 3-(5-phenyloxazol-2-yl)pyridine；Pyridine, 3-(4-phenyl-2-oxazolyl)-；4-phenyl-2-pyridin-3-yl-1,3-oxazole
• CAS: 504415-44-5
• 化学式: C₁₄H₁₀N₂O
• 分子量: 222.246
• InChiKey: WIOBXLBWLVMMAJ-UHFFFAOYSA-N

物化性质

• 沸点：
  414.6±47.0 °C(Predicted)
• 密度：
  1.174±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-4-苯基噁唑 、 3-吡啶硼酸 在 bis-triphenylphosphine-palladium(II) chloride sodium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.33h， 以91%的产率得到3-(4-phenyloxazol-2-yl)pyridine
  参考文献：
  名称：

  Suzuki Coupling of Oxazoles

  摘要：

  A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo-and heterodimeric 4,4-linked dioxazoles.

  DOI：

  10.1021/ol060591j

文献信息

• Suzuki Coupling of Oxazoles
  作者：Emmanuel Ferrer Flegeau、Matthew E. Popkin、Michael F. Greaney

  DOI：10.1021/ol060591j

  日期：2006.6.1

  A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo-and heterodimeric 4,4-linked dioxazoles.