3,5,7-三羟基-3',4',5'-三甲氧基黄酮 | 146132-95-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 3,5,7-三羟基-3',4',5'-三甲氧基黄酮
• 英文名称: Myricetin-trimethylether
• 英文别名: myricetin 3',4',5'-trimethyl ether；3,5,7-trihydroxy-3′,4′,5′-trimethoxyflavone；3',4',5'-O-trimethylmyricetin；3,5,7-trihydroxy-3',4',5'-trimethoxyflavone；3,5,7-trihydroxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one；3,5,7-Trihydroxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-on；ST056257；3,5,7-trihydroxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one
• CAS: 146132-95-8
• 化学式: C₁₈H₁₆O₈
• 分子量: 360.32
• InChiKey: LHNLHJJGLDWGFS-UHFFFAOYSA-N

物化性质

• 熔点：
  288-291°C (dec.)
• 密度：
  1.482
• LogP：
  2.270 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3,5,7-三羟基-3',4',5'-三甲氧基黄酮 在 加尔万氧基自由基 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Kinetic and Stoichiometric Assessment of the Antioxidant Activity of Flavonoids by Electron Spin Resonance Spectroscopy

  摘要：

  dThere is current interest in the use of naturally occurring flavonoids as antioxidants for the preservation of foods and the prevention of diseases such as atherosclerosis and cancers. To establish the molecular characteristics required for maximum antioxidant activity, electron spin resonance (ESR) spectroscopy has been used to determine the stoichiometry and kinetics of the hydrogen-donating ability of 15 flavonoids and D-alpha-tocopherol to galvinoxyl, a resonance-stabilized, sterically protected aryloxyl radical. The second-order reaction rates, which will be governed by O-H bond dissociation energies, were myricetin > morin > quercetin > fisetin similar to catechin > kaempferol similar to luteolin > rutin > D-alpha-tocopherol > taxifolin > tamarixetin > myricetin 3',4',5'-trimethyl ether > datiscetin > galangin > hesperitin similar to apigenin. Reactivity is highly dependant on the configuration of OH groups on the flavonoid B and C rings, there being little contribution from the A ring to antioxidant effectiveness. Highest reaction rates and stoichiometries were observed with flavonols capable of being oxidized to orthoquinones or extended paraquinones. However, rates and stoichiometries did not always correlate and the data suggest that kinetic factors may be of greater importance within a biological context.

  DOI：

  10.1021/jf025922v
• 作为产物：
  描述：

  2'-(苯甲酰氧基)根皮乙酰苯 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium 3,4,5-trimethoxybenzoate 作用下， 生成 3,5,7-三羟基-3',4',5'-三甲氧基黄酮
  参考文献：
  名称：

  Heap; Robinson, Journal of the Chemical Society, 1929, p. 69

  摘要：

  DOI：

文献信息

• Flavonoid compounds as therapeutic antioxidants
  申请人：Caldwell Thomas Stuart

  公开号：US20060137207A1

  公开（公告）日：2006-06-29

  Novel flavonoid compounds having anti-oxidant activity are described. Formula 1. The compounds have been shown to exhibit anti-oxidative properties in biological systems and their utility in a sunscreen or skincare composition or to treat conditions involving oxidative damage, especially curative or prophylactic treatment of Alzheimer's disease or ischaemia-reperfusion injury, is described.

  描述了具有抗氧化活性的新型黄酮类化合物。公式1。已经证明这些化合物在生物系统中表现出抗氧化性质，并描述了它们在防晒霜或护肤组合物中的实用性，或用于治疗涉及氧化损伤的疾病，特别是治疗阿尔茨海默病或缺血再灌注损伤的治疗或预防。
• Tire with rubber containing flavone
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP1391327A1

  公开（公告）日：2004-02-25

  The invention relates to a rubber composition and a pneumatic tire having a component comprising a rubber containing the reaction product of a flavone and a methylene donor.

  本发明涉及一种橡胶组合物和充气轮胎，其成分包括含有黄酮和亚甲基供体反应产物的橡胶。
• Rubber composition and tire with rubber containing flavone
  申请人：The Goodyear Tire & Rubber Company

  公开号：EP2730431A1

  公开（公告）日：2014-05-14

  A rubber composition comprising a diene based elastomer and an adhesion promoter derived from a flavone, a methylene donor and a methylene acceptor is disclosed. The rubber composition is essentially free of cobalt. Also, a pneumatic tire comprising such a rubber composition is disclosed.

  本发明公开了一种橡胶组合物，该组合物包含一种二烯基弹性体和一种由黄酮、亚甲基供体和亚甲基受体衍生的附着力促进剂。该橡胶组合物基本上不含钴。此外，还公开了一种包含这种橡胶组合物的充气轮胎。
• 感染症の治療を目的としたフラボン類、クマリン類および関連化合物の使用
  申请人：プレンダーガスト、パトリック、ティ.

  公开号：JP2003504327A

  公开（公告）日：2003-02-04

  \n (57)【要約】\n本発明は感染症、特にウイルス（例えばHCV、HIV、ピコルナウイルスあるいは呼吸器ウイルス）あるいは寄生虫（例えばトキソプラズマ症）感染症の治療におけるシルシリオール、3'4'-ジアセトキシ-5,6,7-トリメトキシフラボンあるいはナリンギンなどのフラビン類の使用を提供する。また前記方法で使用するための組成物群も提供する。\n

  \(57) [Abstract] The invention provides for the use of silsiliol, 3'4'-diacetoxy-5,6,7-trimethoxyflavone or柚皮苷等黄素的用途。还提供了一组用于上述方法的组合物。\n
• Methods For Treating Wounds
  申请人：Kimberly-Clark Worldwide, Inc.

  公开号：US20030125264A1

  公开（公告）日：2003-07-03

  Pharmaceutical compositions, and methods of using the same, are provided utilizing effective amounts of one or more flavones, flavonols, flavanones, isoflavanones and isoflavones to increase cell proliferation in various tissues and cell lines. As examples, the composition and methods of the present invention can be used to increase proliferation of fibroblast cells and, more particularly, in the treatment of wounds as well as strengthening of the skin.

  本发明提供了利用有效量的一种或多种黄酮、黄酮醇、黄烷酮、异黄烷酮和异黄酮来增加各种组织和细胞系的细胞增殖的药物组合物及其使用方法。举例来说，本发明的组合物和方法可用于增加成纤维细胞的增殖，特别是用于治疗伤口和强化皮肤。