1-[3-(2-Fluoro-4-nitrophenoxy)pyrrolidin-1-yl]-2-phenylmethoxyethanone | 346665-26-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[3-(2-Fluoro-4-nitrophenoxy)pyrrolidin-1-yl]-2-phenylmethoxyethanone
• 英文别名: 1-[3-(2-fluoro-4-nitrophenoxy)pyrrolidin-1-yl]-2-phenylmethoxyethanone
• CAS: 346665-26-7
• 化学式: C₁₉H₁₉FN₂O₅
• 分子量: 374.369
• InChiKey: IVPYMRSFBYSUJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  84.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[3-(2-Fluoro-4-nitrophenoxy)pyrrolidin-1-yl]-2-phenylmethoxyethanone 在 乙醇 、 碳酸氢钠 、 tin(ll) chloride 作用下， 以 丙酮 为溶剂， 生成 {4-[1-(2-Benzyloxy-acetyl)-pyrrolidin-3-yloxy]-3-fluoro-phenyl}-carbamic acid benzyl ester
  参考文献：
  名称：

  Novel piperidinyloxy oxazolidinone antimicrobial agents

  摘要：

  Oxazolidinone antibacterial agents, where the N-substituted piperazinyl group of eperezolid was replaced with a N-substituted piperidinyloxy moiety. were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms. The effect of ring size, positional isomerism, and fluorine substitution on antibacterial activity was examined. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00305-5
• 作为产物：
  描述：

  3,4-二氟硝基苯 、 N-(α-benzyloxyacetyl)pyrrolidin-3-ol 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 以77%的产率得到1-[3-(2-Fluoro-4-nitrophenoxy)pyrrolidin-1-yl]-2-phenylmethoxyethanone
  参考文献：
  名称：

  Novel piperidinyloxy oxazolidinone antimicrobial agents

  摘要：

  Oxazolidinone antibacterial agents, where the N-substituted piperazinyl group of eperezolid was replaced with a N-substituted piperidinyloxy moiety. were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms. The effect of ring size, positional isomerism, and fluorine substitution on antibacterial activity was examined. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00305-5

文献信息

• Novel piperidinyloxy oxazolidinone antimicrobial agents
  作者：Michele A Weidner-Wells、Christine M Boggs、Barbara D Foleno、Ellyn Wira、Karen Bush、Raul M Goldschmidt、Dennis J Hlasta

  DOI：10.1016/s0960-894x(01)00305-5

  日期：2001.7

  Oxazolidinone antibacterial agents, where the N-substituted piperazinyl group of eperezolid was replaced with a N-substituted piperidinyloxy moiety. were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms. The effect of ring size, positional isomerism, and fluorine substitution on antibacterial activity was examined. (C) 2001 Elsevier Science Ltd. All rights reserved.