O²-methyl-D-galactose | 20972-03-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O²-methyl-D-galactose
• 英文别名: 2-O-Methyl-D-galactose；2-O-Methyl-D-galaktose；2-O-Methyl-galactose；2-O-methylgalactopyranose；(3R,4S,5R,6R)-6-(hydroxymethyl)-3-methoxyoxane-2,4,5-triol
• CAS: 20972-03-6
• 化学式: C₇H₁₄O₆
• 分子量: 194.185
• InChiKey: UMPNFVHHMOSNAC-TVPFVARWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 反应 1.0h， 生成 2,3,4-tri-O-methyl-D-galactose 、 2,4,6-Tri-O-methyl-β-D-galactopyranose 、 (3R,4S,5S,6R)-3,4,5-Trimethoxy-6-methoxymethyl-tetrahydro-pyran-2-ol 、 O²-methyl-D-galactose 、 2,3,6-tri-O-methyl-D-galactopyranose 、 O³,O⁴,O⁶-trimethyl-D-galactose 、 (3R,4S,5S,6R)-4-methoxy-6-(methoxymethyl)oxane-2,3,5-triol
  参考文献：
  名称：

  Formation of Homooligosaccharides Using Base-Promoted Glycosylation of Unprotected Glycosyl Fluorides

  摘要：

  Homooligomeric saccharides are of general interest with potential applications in chemical, pharmaceutical, and food industry as well as for materials with novel properties. This contribution describes a methodology of a base-promoted "single step self-oligomerization" of glycosyl fluorides as donors leading to oligomers with up to similar to 25 saccharide units. The influences of base and reaction time were examined. Linkage analysis of the corresponding alditol acetates by GC/MS allowed for calculation of average structural elements of oligomers.

  DOI：

  10.1021/ma100191d

文献信息

• Process for the production of peracylated 1-0-glycosides
  申请人：Schering AG

  公开号：US20030069402A1

  公开（公告）日：2003-04-10

  The invention relates to a process for the production of peracylated 1-O-glycosides of general formula I or salts thereof 1 in which sugar is a monosaccharide that is functionalized in 1-OH-position, R represents methyl, ethyl, propyl, isopropyl, tbutyl, phenyl, n means 2, 3 or 4, X means —COO— or —NH—and L means a straight-chain, branched, saturated or unsaturated C 1 -C 30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of peracylated saccharides with 1-O-functionalized side chains on an enlarged scale.

  该发明涉及一种生产通式I的过酰化1-O-糖苷或其盐的工艺，其中糖是在1-OH位置上被官能化的单糖，R代表甲基、乙基、丙基、异丙基、叔丁基、苯基，n取2、3或4，X代表—COO—或—NH—，L代表一条直链、分支、饱和或不饱和的C1-C30碳链，该碳链可以被基团中断或取代。根据该发明的工艺从经济实惠的起始材料开始，提供良好的产量，并允许在扩大规模上生产具有1-O官能化侧链的过酰化糖苷。
• Process for the production of perbenzylated 1-O-glycosides
  申请人：——

  公开号：US20030055242A1

  公开（公告）日：2003-03-20

  The invention relates to a process for the production of perbenzylated 1-O-glycosides of general formula I or salts thereof 1 in which sugar 1 is a monosaccharide that is functionalized in 1-OH-position, R represents benzyl, n means 2, 3 or 4, X means —COO— or —NH— and L means a straight-chain, branched, saturated or unsaturated C 1 -C 30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of perbenzylated saccharides with 1-O-functionalized side chains on an industrial scale.

  该发明涉及一种生产通式I的过苄基化1-O-糖苷或其盐的方法，其中糖1是在1-OH位置上官能化的单糖，R代表苄基，n为2、3或4，X代表—COO—或—NH—，L代表直链、支链、饱和或不饱和的C1-C30碳链，该碳链可以选择性地被基团中断或取代。根据该发明的方法从经济起始材料开始，提供良好的产率，并允许在工业规模上生产具有1-O官能化侧链的过苄基化糖类。
• Process for the production of perbenzylated 1-0-glycosides
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：US20020002274A1

  公开（公告）日：2002-01-03

  The invention relates to a process for the production of perbenzylated 1-O-glycosides of general formula I or salts thereof 1 in which sugar 1 is a monosaccharide that is functionalized in 1 -OH-position, R represents benzyl, n means 2, 3 or 4, means —O—, —S—, —COO— or —NH— and L means a straight-chain, branched, saturated or unsaturated C 1 -C 30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of perbenzylated saccharides with 1-O-functionalized side chains on an enlarged scale.

  本发明涉及一种生产通式I的1-O-苄基化糖苷或其盐的过程，其中糖1是在1-OH位置上官能化的单糖，R代表苄基，n为2、3或4，代表-O、S、COO或NH，L代表直链、支链、饱和或不饱和的C1-C30碳链，该碳链可以被中断或取代。本发明的过程从经济实惠的起始材料开始，提供良好的产量，并允许在扩大规模上生产1-O官能化侧链的苄基化糖苷。
• [EN] INKT CELL MODULATORS AND METHODS OF USING THE SAME<br/>[FR] MODULATEURS DE CELLULE INKT ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV OXFORD

  公开号：WO2013079687A1

  公开（公告）日：2013-06-06

  Disclosed herein are α-galactosylceramide (α-GalCer) analogs and compositions thereof, methods of activating invariant Natural Killer T (iNKT) cells using said analogs, methods of treating diseases by activating iNKT cells using said analogs, and combination therapy of said analogs.

  本文披露了α-半乳糖基神经酰胺（α-GalCer）类似物及其组合物，使用该类似物激活不变型自然杀伤T细胞（iNKT细胞）的方法，利用该类似物激活iNKT细胞治疗疾病的方法，以及该类似物的联合治疗方法。
• Process for the production of fine chemicals
  申请人：Puzio Piotr

  公开号：US20070118916A1

  公开（公告）日：2007-05-24

  The present invention relates to a process for the production of the fine chemical in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof, preferably in plastids. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.

  本发明涉及一种在微生物、植物细胞、植物、植物组织或其一部分中生产精细化学品的过程，优选在质体中进行。此外，本发明还涉及核酸分子、多肽、核酸构建物、载体、抗体、宿主细胞、植物组织、繁殖材料、收获材料、植物、微生物以及农业组合物以及它们的用途。