2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinecarbothioamide | 302945-51-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinecarbothioamide
• 英文别名: 2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazine carbothioamide；[[1-[(2,4-dichlorophenyl)methyl]indol-3-yl]methylideneamino]thiourea
• CAS: 302945-51-3
• 化学式: C₁₇H₁₄Cl₂N₄S
• 分子量: 377.297
• InChiKey: SSCQKZYDFMSZRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  87.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinecarbothioamide 、 2-溴-4'-氟苯乙酮 以 四氢呋喃 为溶剂， 反应 1.5h， 以to yield the final product (78% yield)的产率得到2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole
  参考文献：
  名称：

  SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF

  摘要：

  本发明涉及新型取代的4-芳基噻唑，其制备方法，以及其作为治疗剂的用途，特别是在结核病的预防或治疗方面。本发明特别涉及A式化合物。

  公开号：

  US20140235863A1
• 作为产物：
  描述：

  氨基硫脲 、 1-(2,4-二氯苄基)-1H-吲哚-3-甲醛 在 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 生成 2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinecarbothioamide
  参考文献：
  名称：

  Synthesis and biological evaluation of substituted 4-arylthiazol-2-amino derivatives as potent growth inhibitors of replicating Mycobacterium tuberculosis H37RV

  摘要：

  In search of potential therapeutics for tuberculosis, we describe herein synthesis and biological evaluation of some substituted 4-arylthiazol-2-amino derivatives as modified analogues of the antiprotozoal drug Nitazoxanide (NTZ), which has recently been reported as potent inhibitor of Mtb H(37)Rv (Mtb MIC = 52.12 mu M) with an excellent ability to evade resistance. Among the synthesized derivatives, the two compounds 7a ( MIC = 15.28 mu M) and 7c (MIC = 17.03 mu M) have exhibited about three times better Mtb growth inhibitory activity over NTZ and are free from any cytotoxicity (Vero CC50 of 244 and 300 mu M respectively). These two compounds represent promising leads for further optimization. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.076

文献信息

• [EN] SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF<br/>[FR] 4-ARYLTHIAZOLES SUBSTITUÉS ET PROCÉDÉ DE PRÉPARATION DE CES DERNIERS
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2012164572A1

  公开（公告）日：2012-12-06

  The present invention relates to novel substituted 4-arylthiazoles, their preparation, and to their use as therapeutic agents, particularly in the prevention or treatment of tuberculosis. The resent invention articularl relates to com ounds of formula A:

  本发明涉及新型取代的4-芳基噻唑化合物，其制备以及作为治疗剂的用途，特别是在预防或治疗结核病方面。该发明特别涉及公式A的化合物。
• SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF
  申请人：Singh Supriya

  公开号：US20140235863A1

  公开（公告）日：2014-08-21

  The present invention relates to novel substituted 4-arylthiazoles, their preparation, and to their use as therapeutic agents, particularly in the prevention or treatment of tuberculosis. The present invention particularly relates to compounds of formula A:

  本发明涉及新型取代的4-芳基噻唑，其制备方法，以及其作为治疗剂的用途，特别是在结核病的预防或治疗方面。本发明特别涉及A式化合物。
• Synthesis and biological evaluation of substituted 4-arylthiazol-2-amino derivatives as potent growth inhibitors of replicating Mycobacterium tuberculosis H37RV
  作者：Kuldeep K. Roy、Supriya Singh、Sandeep K. Sharma、Ranjana Srivastava、Vinita Chaturvedi、Anil K. Saxena

  DOI：10.1016/j.bmcl.2011.06.076

  日期：2011.9

  In search of potential therapeutics for tuberculosis, we describe herein synthesis and biological evaluation of some substituted 4-arylthiazol-2-amino derivatives as modified analogues of the antiprotozoal drug Nitazoxanide (NTZ), which has recently been reported as potent inhibitor of Mtb H(37)Rv (Mtb MIC = 52.12 mu M) with an excellent ability to evade resistance. Among the synthesized derivatives, the two compounds 7a ( MIC = 15.28 mu M) and 7c (MIC = 17.03 mu M) have exhibited about three times better Mtb growth inhibitory activity over NTZ and are free from any cytotoxicity (Vero CC50 of 244 and 300 mu M respectively). These two compounds represent promising leads for further optimization. (C) 2011 Elsevier Ltd. All rights reserved.