9-methoxy-5,11-dimethyl-6H-pyrido<4,3-b>carbazole-1-carbonitrile | 155536-59-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-methoxy-5,11-dimethyl-6H-pyrido<4,3-b>carbazole-1-carbonitrile
• 英文别名: 9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole-1-carbonitrile
• CAS: 155536-59-7
• 化学式: C₁₉H₁₅N₃O
• 分子量: 301.348
• InChiKey: WQUDOZPWNUMEOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  61.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9-methoxy-5,11-dimethyl-6H-pyrido<4,3-b>carbazole-1-carbonitrile 在 sodium hydroxide 、 双氧水 作用下， 以 甲醇 为溶剂， 反应 168.0h， 以64%的产率得到9-methoxy-5,11-dimethyl-6H-pyrido<4,3-b>carbazole-1-carboxamide
  参考文献：
  名称：

  Synthesis of 9-Methoxyellipticine N-Oxide and Its Transformation into 1-Functionalized Ellipticine Derivatives

  摘要：

  9-Methoxy-5,11-dimethyl-(and 5-methyl)-6H-pyrido[4,3-b]carbazole-1-carbonitriles (8) were synthesized through methoxyellipticine N-oxides (4) and subsequent deoxygenation-functionalization by diethyl cyanophosphonate. Hydration of these nitriles (8) into 1-carboxamidoellipticines (9) and cytotoxicities of these last compounds are also reported.

  DOI：

  10.3987/com-93-6587
• 作为产物：
  描述：

  甲氧基-9-椭圆玫瑰树碱乳酸盐 在 三乙胺 、 间氯过氧苯甲酸 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 26.0h， 生成 9-methoxy-5,11-dimethyl-6H-pyrido<4,3-b>carbazole-1-carbonitrile
  参考文献：
  名称：

  Synthesis of 9-Methoxyellipticine N-Oxide and Its Transformation into 1-Functionalized Ellipticine Derivatives

  摘要：

  9-Methoxy-5,11-dimethyl-(and 5-methyl)-6H-pyrido[4,3-b]carbazole-1-carbonitriles (8) were synthesized through methoxyellipticine N-oxides (4) and subsequent deoxygenation-functionalization by diethyl cyanophosphonate. Hydration of these nitriles (8) into 1-carboxamidoellipticines (9) and cytotoxicities of these last compounds are also reported.

  DOI：

  10.3987/com-93-6587

文献信息

• Synthesis of 9-Methoxyellipticine N-Oxide and Its Transformation into 1-Functionalized Ellipticine Derivatives
  作者：Christian Rivalle、Emile Bisagni

  DOI：10.3987/com-93-6587

  日期：——

  9-Methoxy-5,11-dimethyl-(and 5-methyl)-6H-pyrido[4,3-b]carbazole-1-carbonitriles (8) were synthesized through methoxyellipticine N-oxides (4) and subsequent deoxygenation-functionalization by diethyl cyanophosphonate. Hydration of these nitriles (8) into 1-carboxamidoellipticines (9) and cytotoxicities of these last compounds are also reported.