(4-Methyl-pyridin-2-yl)-((S)-1-phenyl-ethyl)-amine | 383426-35-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (4-Methyl-pyridin-2-yl)-((S)-1-phenyl-ethyl)-amine
• 英文别名: 4-methyl-N-[(1S)-1-phenylethyl]pyridin-2-amine
• CAS: 383426-35-5
• 化学式: C₁₄H₁₆N₂
• 分子量: 212.294
• InChiKey: XWUGNHOKRMMXKF-LBPRGKRZSA-N

物化性质

• 沸点：
  344.1±27.0 °C(Predicted)
• 密度：
  1.081±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-Methyl-pyridin-2-yl)-((S)-1-phenyl-ethyl)-amine 在 盐酸 、 氢溴酸 、 溴 、 sodium hexamethyldisilazane 、 溶剂黄146 、 sodium t-butanolate 作用下， 以 四氢呋喃 、 乙醇 、 叔丁醇 为溶剂， 生成 2-(4-fluorophenyl)-3-[2-[[(1S)-1-phenylethyl]amino]pyridin-4-yl]imidazo[1,2-a]pyrimidin-7-amine
  参考文献：
  名称：

  Imidazopyrimidines, potent inhibitors of p38 MAP kinase

  摘要：

  The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-alpha in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01020-x
• 作为产物：
  描述：

  2-溴-4-甲基吡啶 、 (S)-(-)- α-甲基苄胺 在 tris(dibenzylideneacetone)dipalladium (0) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 生成 (4-Methyl-pyridin-2-yl)-((S)-1-phenyl-ethyl)-amine
  参考文献：
  名称：

  Imidazopyrimidines, potent inhibitors of p38 MAP kinase

  摘要：

  The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-alpha in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01020-x

文献信息

• Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes
  作者：Lisa F Frey、Karen Marcantonio、Doug E Frantz、Jerry A Murry、Richard D Tillyer、Edward J.J Grabowski、Paul J Reider

  DOI：10.1016/s0040-4039(01)01428-9

  日期：2001.9

  We recently required an efficient synthesis of 2-halo- and2-alkylamino-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Imidazopyrimidines, potent inhibitors of p38 MAP kinase
  作者：Kenneth C Rupert、James R Henry、John H Dodd、Scott A Wadsworth、Druie E Cavender、Gilbert C Olini、Bohumila Fahmy、John J Siekierka

  DOI：10.1016/s0960-894x(02)01020-x

  日期：2003.2

  The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-alpha in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.