[EN] THIENOMETHYLPIPERAZINE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE<br/>[FR] DÉRIVÉS THIÉNOMÉTHYLPIPÉRAZINE UTILISÉS COMME INHIBITEURS D'ÉPOXYDE HYDROLASE SOLUBLE
申请人:SANOFI SA
公开号:WO2015082474A1
公开(公告)日:2015-06-11
The present invention relates to compounds of the formula (I), wherein R1, R2, R3, R4 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, cardiovascular diseases, inflammatory diseases or could show beneficial effects in pain, dyslipidemia, atherosclerosis wound healing and stroke. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
本发明涉及式(I)的化合物,其中R1、R2、R3、R4和X具有权利要求中所指示的含义。式I的化合物是有价值的药理活性化合物。它们是高效且选择性可溶性环氧化酶抑制剂,例如适用于肾衰竭、糖尿病肾病、2型糖尿病、心血管疾病、炎症性疾病的治疗和预防,或者可能在疼痛、血脂异常、动脉粥样硬化、伤口愈合和中风中显示有益效果。此外,本发明还涉及制备式I化合物的方法,它们的用途,特别是作为药物中的活性成分,以及包含它们的药物制剂。